Complications of Structural Allografts for Malignant Bone Tumours

Yong Koo Kang, Jin Young Jeong, Yang Guk Chung, Won Jong Bahk, Seung Koo Rhee

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

To compare the complications in non-irradiated and irradiated structural allograft for malignant bone tumours, thirty-five patients who had been treated from April 1992 to December 2000 were studied. The duration of follow-up was 1 to 9 years (average 5 years). There were 23 males and 12 females, and age ranged from 1 to 55 years old (average 26 years). Diagnoses were 18 osteosarcomas, 7 chondrosarcomas, 3 malignant giant cell tumours, and 7 in Ewing's sarcoma, plasmacytoma, malignant lymphoma, metastatic tumours. The anatomical locations were 20 femurs, 7 tibiae and 8 humeri. There were 17 deep frozen, non-irradiated allografts supplied by our hospital bone bank. There were 25 irradiated, either deep-frozen or freeze dried allografts. Dosage of the irradiation ranged from 15 to 25. kGy. Reconstruction related complications from all patients developed in 13 patients (37.1%). The complications of the non-irradiated allografts developed in 7 out of 15 (46.6%), included infection in 3, delayed or non-union in 3, and graft fracture in 1. The complications of the irradiated allograft developed in 6 out of 20 (30%), included infection in 1, delayed or non-union in 2 and graft fracture in 3. The complications of irradiated allografts were relatively less, especially infection. However, the graft fracture of irradiated allografts were high. Delayed or non-union and graft fractures were salvageable with rigid internal fixation and autogenous bone graft. However, infections were difficult to salvage.

Original languageEnglish
Title of host publicationSterilisation of Tissues Using Ionising Radiations
PublisherElsevier Inc.
Pages157-162
Number of pages6
ISBN (Print)1855738384, 9781855738386
DOIs
StatePublished - 6 May 2005

Bibliographical note

Publisher Copyright:
© 2005, Woodhead Publishing Ltd. All rights reserved.

Keywords

  • Allograft
  • Bone tumour
  • Complication
  • Irradiation
  • Sterilisation

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