Abstract
To compare the complications in non-irradiated and irradiated structural allograft for malignant bone tumours, thirty-five patients who had been treated from April 1992 to December 2000 were studied. The duration of follow-up was 1 to 9 years (average 5 years). There were 23 males and 12 females, and age ranged from 1 to 55 years old (average 26 years). Diagnoses were 18 osteosarcomas, 7 chondrosarcomas, 3 malignant giant cell tumours, and 7 in Ewing's sarcoma, plasmacytoma, malignant lymphoma, metastatic tumours. The anatomical locations were 20 femurs, 7 tibiae and 8 humeri. There were 17 deep frozen, non-irradiated allografts supplied by our hospital bone bank. There were 25 irradiated, either deep-frozen or freeze dried allografts. Dosage of the irradiation ranged from 15 to 25. kGy. Reconstruction related complications from all patients developed in 13 patients (37.1%). The complications of the non-irradiated allografts developed in 7 out of 15 (46.6%), included infection in 3, delayed or non-union in 3, and graft fracture in 1. The complications of the irradiated allograft developed in 6 out of 20 (30%), included infection in 1, delayed or non-union in 2 and graft fracture in 3. The complications of irradiated allografts were relatively less, especially infection. However, the graft fracture of irradiated allografts were high. Delayed or non-union and graft fractures were salvageable with rigid internal fixation and autogenous bone graft. However, infections were difficult to salvage.
Original language | English |
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Title of host publication | Sterilisation of Tissues Using Ionising Radiations |
Publisher | Elsevier Inc. |
Pages | 157-162 |
Number of pages | 6 |
ISBN (Print) | 1855738384, 9781855738386 |
DOIs | |
State | Published - 6 May 2005 |
Bibliographical note
Publisher Copyright:© 2005, Woodhead Publishing Ltd. All rights reserved.
Keywords
- Allograft
- Bone tumour
- Complication
- Irradiation
- Sterilisation