Concomitant ATTR and AL Cardiac Amyloidosis With Matching 99mTc-DPD Scintigraphy and 18F-Flutemetamol PET/CT

Joo O. Hyun; Jong Chan Youn; Eun Ji Han; Mi Hyang Jung; Jung Yeon Lee; Sung Soo Park; Yeoun Eun Sung; Chang Ki Min

doi:10.1097/RLU.0000000000005784

Concomitant ATTR and AL Cardiac Amyloidosis With Matching ^99mTc-DPD Scintigraphy and ¹⁸F-Flutemetamol PET/CT

Joo O. Hyun, Jong Chan Youn, Eun Ji Han, Mi Hyang Jung, Jung Yeon Lee, Sung Soo Park, Yeoun Eun Sung, Chang Ki Min

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two distinct types of systemic amyloidosis—transthyretin (ATTR) and light chain (AL)—account for the majority of cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an amyloid deposit. We present a rare occurrence of histopathologically confirmed concomitant ATTR and AL CA captured on ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and ¹⁸F-flutemetamol (FMM) PET/CT.

Original language	English
Pages (from-to)	460-461
Number of pages	2
Journal	Clinical Nuclear Medicine
Volume	50
Issue number	5
DOIs	https://doi.org/10.1097/RLU.0000000000005784
State	Published - 1 May 2025

Bibliographical note

Publisher Copyright:
Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

F-flutemetamol
amyloid PET
amyloidosis
concomitant
light chain
transthyretin

Access to Document

10.1097/RLU.0000000000005784

Cite this

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title = "Concomitant ATTR and AL Cardiac Amyloidosis With Matching 99mTc-DPD Scintigraphy and 18F-Flutemetamol PET/CT",

abstract = "Two distinct types of systemic amyloidosis—transthyretin (ATTR) and light chain (AL)—account for the majority of cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an amyloid deposit. We present a rare occurrence of histopathologically confirmed concomitant ATTR and AL CA captured on 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and 18F-flutemetamol (FMM) PET/CT.",

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AU - Youn, Jong Chan

AU - Han, Eun Ji

AU - Jung, Mi Hyang

AU - Lee, Jung Yeon

AU - Park, Sung Soo

AU - Sung, Yeoun Eun

AU - Min, Chang Ki

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AB - Two distinct types of systemic amyloidosis—transthyretin (ATTR) and light chain (AL)—account for the majority of cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an amyloid deposit. We present a rare occurrence of histopathologically confirmed concomitant ATTR and AL CA captured on 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and 18F-flutemetamol (FMM) PET/CT.

KW - F-flutemetamol

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