Abstract
Core/shell macrobeads, composed of a hydrogel core and a biodegradable polymeric shell, were designed and evaluated for the protection of islets from both fibrous tissue development as well as the modulation of the immune system rejection response. The core/shell macrobeads (2,000μm diameter) were prepared with approximately 150μm thick polymeric shells. Islets isolated from pancreas of C57/BL6 mice were encapsulated in these core/shell macrobeads. The islets-loaded core/shell macrobeads were planted in the peritoneal cavity of diabetes mellitus-induced C57/BL6 mice and the blood glucose concentrations were measured.
| Original language | English |
|---|---|
| Pages (from-to) | 71-81 |
| Number of pages | 11 |
| Journal | Journal of Bioactive and Compatible Polymers |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Biodegradeable
- Blood glucose
- Coreshell
- Hydrogel
- Immune system
- Islets
- Macrobeads
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