Correlations in the T-cell response to altered peptide ligands

Jeong Man Park; Michael W. Deem

doi:10.1016/j.physa.2004.04.127

Correlations in the T-cell response to altered peptide ligands

Jeong Man Park, Michael W. Deem

Physics

Rice University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of pre-existing T-cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T-cell immune responses. The nonlinear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level diversity of the T-cell repertoire drives the dynamics of the immune response against mutated viral antigens.

Original language	English
Pages (from-to)	455-470
Number of pages	16
Journal	Physica A: Statistical Mechanics and its Applications
Volume	341
Issue number	1-4
DOIs	https://doi.org/10.1016/j.physa.2004.04.127
State	Published - 1 Oct 2004

Bibliographical note

Funding Information:
It is a pleasure to acknowledge stimulating discussions with Michael A. Barry. This research was supported by the National Institutes of Health and the National Science Foundation.

Keywords

Altered peptide ligands
Immune system
Random energy model

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10.1016/j.physa.2004.04.127

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title = "Correlations in the T-cell response to altered peptide ligands",

abstract = "The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of pre-existing T-cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T-cell immune responses. The nonlinear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level diversity of the T-cell repertoire drives the dynamics of the immune response against mutated viral antigens.",

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AU - Deem, Michael W.

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AB - The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of pre-existing T-cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T-cell immune responses. The nonlinear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level diversity of the T-cell repertoire drives the dynamics of the immune response against mutated viral antigens.

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KW - Immune system

KW - Random energy model

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IS - 1-4

ER -

Correlations in the T-cell response to altered peptide ligands

Abstract

Bibliographical note

Keywords

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