Cost-Effectiveness of Fractional FlowReserve-Guided Treatment for Acute Myocardial Infarction and Multivessel Disease A Prespecified Analysis of the FRAME-AMI Randomized Clinical Trial

IMPORTANCE Complete revascularization by non-infarct-related artery (IRA) percutaneous coronary intervention (PCI) in patients with acutemyocardial infarction is standard practice to improve patient prognosis. However, it is unclear whether a fractional flow reserve (FFR)-guided or angiography-guided treatment strategy for non-IRA PCI would be more cost-effective. OBJECTIVE To evaluate the cost-effectiveness of FFR-guided compared with angiography-guided PCI in patients with acutemyocardial infarction and multivessel disease. DESIGN, SETTING, AND PARTICIPANTS In this prespecified cost-effectiveness analysis of the FRAME-AMI randomized clinical trial, patients were randomly allocated to either FFR-guided or angiography-guided PCI for non-IRA lesions between August 19, 2016, and December 24, 2020. Patients were aged 19 years or older, had ST-segment elevationmyocardial infarction (STEMI) or non-STEMI and underwent successful primary or urgent PCI, and had at least 1 non-IRA lesion (diameter stenosis > 50% in a major epicardial coronary artery or major side branch with a vessel diameter of ≥2.0 mm). Data analysis was performed on August 27, 2023. INTERVENTION Fractional flow reserve-guided vs angiography-guided PCI for non-IRA lesions. MAIN OUTCOMES AND MEASURES The model simulated death, myocardial infarction, and repeat revascularization. Future medical costs and benefits were discounted by 4.5%per year. The main outcomes were quality-adjusted life-years (QALYs), direct medical costs, incremental costeffectiveness ratio (ICER), and incremental net monetary benefit (INB) of FFR-guided PCI compared with angiography-guided PCI. State-transition Markov models were applied to the Korean, US, and European health care systems using medical cost (presented in US dollars), utilities data, and transition probabilities from meta-analysis of previous trials. RESULTS The FRAME-AMI trial randomized 562 patients, with a mean (SD) age of 63.3 (11.4) years. Most patients were men (474 [84.3%]). Fractional flow reserve-guided PCI increased QALYs by 0.06 compared with angiography-guided PCI. The total cumulative cost per patient was estimated as $1208 less for FFR-guided compared with angiography-guided PCI. The ICER was -$19 484 and the INB was $3378, indicating that FFR-guided PCI was more cost-effective for patients with acute myocardial infarction and multivessel disease. Probabilistic sensitivity analysis showed consistent results and the likelihood iteration of cost-effectiveness in FFR-guided PCI was 97%. When transition probabilities from the pairwise meta-analysis of the FLOWER-MI and FRAME-AMI trials were used, FFR-guided PCI was more cost-effective than angiography-guided PCI in the Korean, US, and European health care systems, with an INB of $3910, $8557, and $2210, respectively. In probabilistic sensitivity analysis, the likelihood iteration of cost-effectiveness with FFR-guided PCIwas 85%, 82%, and 31% for the Korean, US, and European health care systems, respectively. CONCLUSIONS AND RELEVANCE This cost-effectiveness analysis suggests that FFR-guided PCI for non-IRA lesions saved medical costs and increased quality of life better than angiography-guided PCI for patients with acute myocardial infarction and multivessel disease. Fractional flow reserve- guided PCI should be considered in determining the treatment strategy for non-IRA stenoses in these patients.