Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

Chang Ki Min; Seok Lee; Yoo Jin Kim; Ki Seong Eom; Jong Wook Lee; Woo Sung Min; Chun Choo Kim; Chul Soo Cho; Gyeongsin Park

doi:10.1111/j.0902-4441.2005.t01-1-EJH2437.x

Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

Chang Ki Min, Seok Lee, Yoo Jin Kim, Ki Seong Eom, Jong Wook Lee, Woo Sung Min, Chun Choo Kim, Chul Soo Cho, Gyeongsin Park

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50 Scopus citations

Abstract

The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	European Journal of Haematology
Volume	76
Issue number	3
DOIs	https://doi.org/10.1111/j.0902-4441.2005.t01-1-EJH2437.x
State	Published - Mar 2006

Keywords

Bortezomib
IL-6
Leucolcastic vasculitis
Multiple myeloma
TNF-α

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10.1111/j.0902-4441.2005.t01-1-EJH2437.x

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title = "Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines",

abstract = "The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.",

keywords = "Bortezomib, IL-6, Leucolcastic vasculitis, Multiple myeloma, TNF-α",

author = "Min, {Chang Ki} and Seok Lee and Kim, {Yoo Jin} and Eom, {Ki Seong} and Lee, {Jong Wook} and Min, {Woo Sung} and Kim, {Chun Choo} and Cho, {Chul Soo} and Gyeongsin Park",

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doi = "10.1111/j.0902-4441.2005.t01-1-EJH2437.x",

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AU - Min, Chang Ki

AU - Lee, Seok

AU - Kim, Yoo Jin

AU - Eom, Ki Seong

AU - Lee, Jong Wook

AU - Min, Woo Sung

AU - Kim, Chun Choo

AU - Cho, Chul Soo

AU - Park, Gyeongsin

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AB - The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.

KW - Bortezomib

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KW - Leucolcastic vasculitis

KW - Multiple myeloma

KW - TNF-α

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Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

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Keywords

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