Abstract
Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This review focuses on the role of cytokines, including IL-21 and IL-4, in regulating B cell responses within the GC, such as differentiation, affinity maturation, and plasma cell development. Additionally, this review explores the impact of other cytokines like CXCL13, IL-10, IL-9, and IL-2 on GC responses and their potential involvement in autoimmune diseases, allergies, and cancer. This review highlights contributions of Tfh-derived cytokines to both protective immunity and immunopathology across a spectrum of diseases. A deeper understanding of Tfh cytokine biology holds promise for insights into biomedical conditions.
| Original language | English |
|---|---|
| Article number | e8 |
| Journal | Immune Network |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2024 |
Bibliographical note
Publisher Copyright:© 2024. The Korean Association of Immunologists.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- B cell
- Cytokine
- Follicular helper T cell
- Germinal center
- Plasma cell
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Findings from Catholic University of Korea in Cytokines Reported (Cytokines In Follicular Helper T Cell Biology In Physiologic and Pathologic Conditions)
12/04/24
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