Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments

Sungwoong Jeon; Sun Hwa Park; Sung Won Kim; Jin Young Kim; Hongsoo Choi

doi:10.1109/MEMS46641.2020.9056365

Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments

Sungwoong Jeon
, Sun Hwa Park
, Sung Won Kim
, Jin Young Kim
, Hongsoo Choi

Department of Otorhinolaryngology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

Here, we propose magnetically driven microrobots for targeted cell delivery that can efficiently swim in various physiological environments. The three-dimensional (3D) microrobots were sophisticatedly fabricated by using micro-electro-mechanical systems (MEMS) technologies such as 3D laser lithography and metal sputtering. The magnetic field generated by an electromagnetic coil system allows efficient wireless actuation of the microrobots, which was characterized in various physiological conditions (in vitro viscous fluid, ex vivo rat brain blood vessels and a live nude mouse intraperitoneal cavity (in vivo)). Especially, the microrobots demonstrated stem cell transportation inside the body cavity of the nude mouse as a proof of concept of targeted cell delivery. Through this study, the use of the proposed microrobots has shown the feasibility of future applications in precision medicine.

Original language	English
Title of host publication	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2-5
Number of pages	4
ISBN (Electronic)	9781728135809
DOIs	https://doi.org/10.1109/MEMS46641.2020.9056365
State	Published - Jan 2020
Event	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada Duration: 18 Jan 2020 → 22 Jan 2020

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2020-January
ISSN (Print)	1084-6999

Conference

Conference	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Country/Territory	Canada
City	Vancouver
Period	18/01/20 → 22/01/20

Bibliographical note

Publisher Copyright:
© 2020 IEEE.

Keywords

3D laser lithography
Cell delivery
In vivo
Magnetic actuation
Microrobot

Access to Document

10.1109/MEMS46641.2020.9056365

Cite this

Jeon, S., Park, S. H., Kim, S. W., Kim, J. Y., & Choi, H. (2020). Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 2-5). Article 9056365 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS46641.2020.9056365

Jeon, Sungwoong ; Park, Sun Hwa ; Kim, Sung Won et al. / Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments. 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 2-5 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments",

abstract = "Here, we propose magnetically driven microrobots for targeted cell delivery that can efficiently swim in various physiological environments. The three-dimensional (3D) microrobots were sophisticatedly fabricated by using micro-electro-mechanical systems (MEMS) technologies such as 3D laser lithography and metal sputtering. The magnetic field generated by an electromagnetic coil system allows efficient wireless actuation of the microrobots, which was characterized in various physiological conditions (in vitro viscous fluid, ex vivo rat brain blood vessels and a live nude mouse intraperitoneal cavity (in vivo)). Especially, the microrobots demonstrated stem cell transportation inside the body cavity of the nude mouse as a proof of concept of targeted cell delivery. Through this study, the use of the proposed microrobots has shown the feasibility of future applications in precision medicine.",

keywords = "3D laser lithography, Cell delivery, In vivo, Magnetic actuation, Microrobot",

author = "Sungwoong Jeon and Park, \{Sun Hwa\} and Kim, \{Sung Won\} and Kim, \{Jin Young\} and Hongsoo Choi",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 ; Conference date: 18-01-2020 Through 22-01-2020",

year = "2020",

month = jan,

doi = "10.1109/MEMS46641.2020.9056365",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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Jeon, S, Park, SH, Kim, SW, Kim, JY & Choi, H 2020, Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments. in 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020., 9056365, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2020-January, Institute of Electrical and Electronics Engineers Inc., pp. 2-5, 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, Vancouver, Canada, 18/01/20. https://doi.org/10.1109/MEMS46641.2020.9056365

Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments. / Jeon, Sungwoong; Park, Sun Hwa; Kim, Sung Won et al.
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 2-5 9056365 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Choi, Hongsoo

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AB - Here, we propose magnetically driven microrobots for targeted cell delivery that can efficiently swim in various physiological environments. The three-dimensional (3D) microrobots were sophisticatedly fabricated by using micro-electro-mechanical systems (MEMS) technologies such as 3D laser lithography and metal sputtering. The magnetic field generated by an electromagnetic coil system allows efficient wireless actuation of the microrobots, which was characterized in various physiological conditions (in vitro viscous fluid, ex vivo rat brain blood vessels and a live nude mouse intraperitoneal cavity (in vivo)). Especially, the microrobots demonstrated stem cell transportation inside the body cavity of the nude mouse as a proof of concept of targeted cell delivery. Through this study, the use of the proposed microrobots has shown the feasibility of future applications in precision medicine.

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Jeon S, Park SH, Kim SW, Kim JY, Choi H. Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 2-5. 9056365. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS46641.2020.9056365

Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

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Cite this