Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway

Hyunjin Lee; Minji Kim; Yun Hee Park; Jun Beom Park

doi:10.1007/s10529-017-2493-0

Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway

Hyunjin Lee, Minji Kim, Yun Hee Park, Jun Beom Park

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objectives: To evaluate the effects of dexamethasone on the aging of mesenchymal stem cells from human gingiva using next-generation sequencing. Results: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Conclusions: Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression of EDN1 of stem cells.

Original language	English
Pages (from-to)	509-519
Number of pages	11
Journal	Biotechnology Letters
Volume	40
Issue number	3
DOIs	https://doi.org/10.1007/s10529-017-2493-0
State	Published - 1 Mar 2018

Bibliographical note

Funding Information:
Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technology & Future Planning (NRF-2017R1A1A1A05001307).

Publisher Copyright:
© 2018, Springer Science+Business Media B.V., part of Springer Nature.

Keywords

Aging
Dexamethasone
Gingiva
Messenger RNA
Stem cells

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10.1007/s10529-017-2493-0

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title = "Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway",

abstract = "Objectives: To evaluate the effects of dexamethasone on the aging of mesenchymal stem cells from human gingiva using next-generation sequencing. Results: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Conclusions: Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression of EDN1 of stem cells.",

keywords = "Aging, Dexamethasone, Gingiva, Messenger RNA, Stem cells",

author = "Hyunjin Lee and Minji Kim and Park, {Yun Hee} and Park, {Jun Beom}",

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AU - Kim, Minji

AU - Park, Yun Hee

AU - Park, Jun Beom

N1 - Funding Information: Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technology & Future Planning (NRF-2017R1A1A1A05001307). Publisher Copyright: © 2018, Springer Science+Business Media B.V., part of Springer Nature.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objectives: To evaluate the effects of dexamethasone on the aging of mesenchymal stem cells from human gingiva using next-generation sequencing. Results: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Conclusions: Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression of EDN1 of stem cells.

AB - Objectives: To evaluate the effects of dexamethasone on the aging of mesenchymal stem cells from human gingiva using next-generation sequencing. Results: Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Conclusions: Application of dexamethasone reduced the expression of SIRT1 and IL6 but enhanced the expression of EDN1 of stem cells.

KW - Aging

KW - Dexamethasone

KW - Gingiva

KW - Messenger RNA

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Dexamethasone downregulates SIRT1 and IL6 and upregulates EDN1 genes in stem cells derived from gingivae via the AGE/RAGE pathway

Abstract

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Keywords

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