Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima - Media thickness in type 2 diabetes

Eun Sook Kim; Sung Dae Moon; Hun Sung Kim; Dong Jun Lim; Jae Hyoung Cho; Hyuk Sang Kwon; Chul Woo Ahn; Kun Ho Yoon; Moo Il Kang; Bong Yun Cha; Ho Young Son

doi:10.2337/dc10-2222

Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima - Media thickness in type 2 diabetes

Eun Sook Kim, Sung Dae Moon, Hun Sung Kim, Dong Jun Lim, Jae Hyoung Cho, Hyuk Sang Kwon, Chul Woo Ahn, Kun Ho Yoon, Moo Il Kang, Bong Yun Cha, Ho Young Son

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE-This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima - media thickness (IMT). RESEARCHDESIGNANDMETHODS-Weconducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffnesswas assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS-Patients with DPN had higher CAVI than those without DPN in multivariateadjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In themultivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001). CONCLUSIONS-DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.

Original language	English
Pages (from-to)	1403-1405
Number of pages	3
Journal	Diabetes Care
Volume	34
Issue number	6
DOIs	https://doi.org/10.2337/dc10-2222
State	Published - Jun 2011

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@article{a878dc6c5ac0456c9415725f5abe060e,

title = "Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima - Media thickness in type 2 diabetes",

abstract = "OBJECTIVE-This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima - media thickness (IMT). RESEARCHDESIGNANDMETHODS-Weconducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffnesswas assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS-Patients with DPN had higher CAVI than those without DPN in multivariateadjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In themultivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95\% CI 1.13-1.65], P = 0.001). CONCLUSIONS-DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.",

author = "Kim, \{Eun Sook\} and Moon, \{Sung Dae\} and Kim, \{Hun Sung\} and Lim, \{Dong Jun\} and Cho, \{Jae Hyoung\} and Kwon, \{Hyuk Sang\} and Ahn, \{Chul Woo\} and Yoon, \{Kun Ho\} and Kang, \{Moo Il\} and Cha, \{Bong Yun\} and Son, \{Ho Young\}",

year = "2011",

month = jun,

doi = "10.2337/dc10-2222",

language = "English",

volume = "34",

pages = "1403--1405",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association Inc.",

number = "6",

}

TY - JOUR

T1 - Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima - Media thickness in type 2 diabetes

AU - Kim, Eun Sook

AU - Moon, Sung Dae

AU - Kim, Hun Sung

AU - Lim, Dong Jun

AU - Cho, Jae Hyoung

AU - Kwon, Hyuk Sang

AU - Ahn, Chul Woo

AU - Yoon, Kun Ho

AU - Kang, Moo Il

AU - Cha, Bong Yun

AU - Son, Ho Young

PY - 2011/6

Y1 - 2011/6

N2 - OBJECTIVE-This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima - media thickness (IMT). RESEARCHDESIGNANDMETHODS-Weconducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffnesswas assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS-Patients with DPN had higher CAVI than those without DPN in multivariateadjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In themultivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001). CONCLUSIONS-DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.

AB - OBJECTIVE-This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima - media thickness (IMT). RESEARCHDESIGNANDMETHODS-Weconducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffnesswas assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS-Patients with DPN had higher CAVI than those without DPN in multivariateadjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In themultivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13-1.65], P = 0.001). CONCLUSIONS-DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.

UR - https://www.scopus.com/pages/publications/80051985137

U2 - 10.2337/dc10-2222

DO - 10.2337/dc10-2222

M3 - Article

C2 - 21515840

AN - SCOPUS:80051985137

SN - 1935-5548

VL - 34

SP - 1403

EP - 1405

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

Diabetic peripheral neuropathy is associated with increased arterial stiffness without changes in carotid intima - Media thickness in type 2 diabetes

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