Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Ki Tae Suk; Dong Joon Kim; Chang Hoon Kim; Seung Ha Park; Jae Youn Cheong; Sung Won Cho; Jong Young Choi; Kwang Hyub Han; Ho Taik Sung; So Hyung Hong; Dae Yong Kim; Jai Hoon Yoon; Yeon Soo Kim; Gwang Ho Baik; Jin Bong Kim

doi:10.1016/j.clinbiochem.2012.04.031

Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Ki Tae Suk
, Dong Joon Kim
, Chang Hoon Kim
, Seung Ha Park
, Jae Youn Cheong
, Sung Won Cho
, Jong Young Choi
, Kwang Hyub Han
, Ho Taik Sung
, So Hyung Hong
, Dae Yong Kim
, Jai Hoon Yoon
, Yeon Soo Kim
, Gwang Ho Baik
, Jin Bong Kim

Division of Gastroenterology

Hallym University
SUNY Upstate Medical University
Inje University
Ajou University
Yonsei University
Stanford University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

Original language	English
Pages (from-to)	1075-1080
Number of pages	6
Journal	Clinical Biochemistry
Volume	45
Issue number	13-14
DOIs	https://doi.org/10.1016/j.clinbiochem.2012.04.031
State	Published - Sep 2012

Bibliographical note

Funding Information:
This research was partly supported by a grant from the Ministry of Health and Welfare, Republic of Korea (no. A050021 ) and also by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2010–0021482 ).

Funding Information:
Financial support: this research was supported by a grant from the Ministry of Health and Welfare, Republic of Korea ( A102065 ) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011–0026601 ).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biological markers
Diagnosis
Extracellular matrix
Hepatic veins
Liver fibrosis

Access to Document

10.1016/j.clinbiochem.2012.04.031

Cite this

Suk, K. T., Kim, D. J., Kim, C. H., Park, S. H., Cheong, J. Y., Cho, S. W., Choi, J. Y., Han, K. H., Sung, H. T., Hong, S. H., Kim, D. Y., Yoon, J. H., Kim, Y. S., Baik, G. H., & Kim, J. B. (2012). Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis. Clinical Biochemistry, 45(13-14), 1075-1080. https://doi.org/10.1016/j.clinbiochem.2012.04.031

@article{51455f6f9d6d4b6c823668c746963688,

title = "Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis",

abstract = "Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 {\texttimes} MMP2. - 0.019 {\texttimes} haptoglobin and - 0.270 + 0.007 {\texttimes} HA. - 0.018 {\texttimes} haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.",

keywords = "Biological markers, Diagnosis, Extracellular matrix, Hepatic veins, Liver fibrosis",

author = "Suk, \{Ki Tae\} and Kim, \{Dong Joon\} and Kim, \{Chang Hoon\} and Park, \{Seung Ha\} and Cheong, \{Jae Youn\} and Cho, \{Sung Won\} and Choi, \{Jong Young\} and Han, \{Kwang Hyub\} and Sung, \{Ho Taik\} and Hong, \{So Hyung\} and Kim, \{Dae Yong\} and Yoon, \{Jai Hoon\} and Kim, \{Yeon Soo\} and Baik, \{Gwang Ho\} and Kim, \{Jin Bong\}",

note = "Funding Information: This research was partly supported by a grant from the Ministry of Health and Welfare, Republic of Korea (no. A050021 ) and also by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2010{\textendash}0021482 ). Funding Information: Financial support: this research was supported by a grant from the Ministry of Health and Welfare, Republic of Korea ( A102065 ) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011{\textendash}0026601 ). ",

year = "2012",

month = sep,

doi = "10.1016/j.clinbiochem.2012.04.031",

language = "English",

volume = "45",

pages = "1075--1080",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

number = "13-14",

}

Suk, KT, Kim, DJ, Kim, CH, Park, SH, Cheong, JY, Cho, SW, Choi, JY, Han, KH, Sung, HT, Hong, SH, Kim, DY, Yoon, JH, Kim, YS, Baik, GH & Kim, JB 2012, 'Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis', Clinical Biochemistry, vol. 45, no. 13-14, pp. 1075-1080. https://doi.org/10.1016/j.clinbiochem.2012.04.031

TY - JOUR

T1 - Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

AU - Suk, Ki Tae

AU - Kim, Dong Joon

AU - Kim, Chang Hoon

AU - Park, Seung Ha

AU - Cheong, Jae Youn

AU - Cho, Sung Won

AU - Choi, Jong Young

AU - Han, Kwang Hyub

AU - Sung, Ho Taik

AU - Hong, So Hyung

AU - Kim, Dae Yong

AU - Yoon, Jai Hoon

AU - Kim, Yeon Soo

AU - Baik, Gwang Ho

AU - Kim, Jin Bong

N1 - Funding Information: This research was partly supported by a grant from the Ministry of Health and Welfare, Republic of Korea (no. A050021 ) and also by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2010–0021482 ). Funding Information: Financial support: this research was supported by a grant from the Ministry of Health and Welfare, Republic of Korea ( A102065 ) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011–0026601 ).

PY - 2012/9

Y1 - 2012/9

N2 - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

AB - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

KW - Biological markers

KW - Diagnosis

KW - Extracellular matrix

KW - Hepatic veins

KW - Liver fibrosis

UR - https://www.scopus.com/pages/publications/84866024116

U2 - 10.1016/j.clinbiochem.2012.04.031

DO - 10.1016/j.clinbiochem.2012.04.031

M3 - Article

C2 - 22579966

AN - SCOPUS:84866024116

SN - 0009-9120

VL - 45

SP - 1075

EP - 1080

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 13-14

ER -

Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Abstract

Bibliographical note

UN SDGs

Keywords

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