Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer

M. J. Song; S. H. Lee; M. R. Choi; H. J. Son; C. W. Lee; J. H. Yoon; Y. G. Park; S. Y. Hur; K. S. Ryu; J. M. Lee

Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer

M. J. Song, S. H. Lee, M. R. Choi, H. J. Son, C. W. Lee, J. H. Yoon, Y. G. Park, S. Y. Hur, K. S. Ryu, J. M. Lee

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p < 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.

Original language	English
Pages (from-to)	148-151
Number of pages	4
Journal	European Journal of Gynaecological Oncology
Volume	34
Issue number	2
State	Published - 2013

Keywords

Advanced ovarian cancer, CA-125
Early detection of recurrence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{a8d096371aa84c8483e03af9c6b797fc,

title = "Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer",

abstract = "Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p < 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.",

keywords = "Advanced ovarian cancer, CA-125, Early detection of recurrence",

author = "Song, {M. J.} and Lee, {S. H.} and Choi, {M. R.} and Son, {H. J.} and Lee, {C. W.} and Yoon, {J. H.} and Park, {Y. G.} and Hur, {S. Y.} and Ryu, {K. S.} and Lee, {J. M.}",

year = "2013",

language = "English",

volume = "34",

pages = "148--151",

journal = "European Journal of Gynaecological Oncology",

issn = "0392-2936",

publisher = "MRE Press",

number = "2",

}

TY - JOUR

T1 - Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer

AU - Song, M. J.

AU - Lee, S. H.

AU - Choi, M. R.

AU - Son, H. J.

AU - Lee, C. W.

AU - Yoon, J. H.

AU - Park, Y. G.

AU - Hur, S. Y.

AU - Ryu, K. S.

AU - Lee, J. M.

PY - 2013

Y1 - 2013

N2 - Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p < 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.

AB - Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p < 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.

KW - Advanced ovarian cancer, CA-125

KW - Early detection of recurrence

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M3 - Article

C2 - 23781586

AN - SCOPUS:84877352166

SN - 0392-2936

VL - 34

SP - 148

EP - 151

JO - European Journal of Gynaecological Oncology

JF - European Journal of Gynaecological Oncology

IS - 2

ER -

Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer

Abstract

Keywords

UN SDGs

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