Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI

Jun Seung Baik; Joon Yong Jung; Won Hee Jee; Chang Woo Chun; Sun Ki Kim; Seung Han Shin; Yang Guk Chung; Chan Kwon Jung; Stephan Kannengiesser; Yo Han Sohn

doi:10.1002/jmri.25536

Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI

Jun Seung Baik
, Joon Yong Jung
, Won Hee Jee
, Chang Woo Chun
, Sun Ki Kim
, Seung Han Shin
, Yang Guk Chung
, Chan Kwon Jung
, Stephan Kannengiesser
, Yo Han Sohn

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Purpose: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities. Materials and Methods: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SI_b-800), apparent diffusion coefficient (ADC), IVIM parameters (D_slow, D_fast, and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, K^trans, k_ep, and v_e). The MR characteristics and parameters from benign and malignant lesions were compared with a chi-squared test and the Mann–Whitney U-test, respectively. The area under receiver operating characteristic (ROC) curves (AUC) of each sequence were also compared. Interobserver agreements were assessed with Cohen's κ, and intraclass correlation coefficient (ICC). Results: ADC, D_slow, and Ff demonstrated a significant difference between benign and malignant marrow abnormalities for both readers (P < 0.001). SI_b-800 and perfusion-related parameters from IVIM-DWI and DCE were not significantly different between the two groups (P = 0.145, 0.439, and 0.337 for reader 1, P = 0.378, 0.368, and 0.343 for reader 2, respectively). The AUCs of ADC, D_slow, and Ff were significantly higher for differentiating indeterminate marrow abnormalities in both readers (P < 0.001). Interobserver agreements were substantial in SI_b-800, and ICCs were almost perfect for ADC, D_slow, f, and Ff, and substantial for iAUC, k_ep, K^trans, v_e, and D_fast. Conclusion: ADC, D_slow, and Ff may provide information for differentiating focal indeterminate abnormalities. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:49–60.

Original language	English
Pages (from-to)	49-60
Number of pages	12
Journal	Journal of Magnetic Resonance Imaging
Volume	46
Issue number	1
DOIs	https://doi.org/10.1002/jmri.25536
State	Published - Jul 2017

Bibliographical note

Publisher Copyright:
© 2016 International Society for Magnetic Resonance in Medicine

Keywords

bone marrow
chemical shift
dynamic contrast-enhanced imaging
intravoxel incoherent motion

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10.1002/jmri.25536

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@article{6cc57d127c12451085f963dfd53abc82,

title = "Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI",

abstract = "Purpose: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities. Materials and Methods: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast, and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, Ktrans, kep, and ve). The MR characteristics and parameters from benign and malignant lesions were compared with a chi-squared test and the Mann–Whitney U-test, respectively. The area under receiver operating characteristic (ROC) curves (AUC) of each sequence were also compared. Interobserver agreements were assessed with Cohen's κ, and intraclass correlation coefficient (ICC). Results: ADC, Dslow, and Ff demonstrated a significant difference between benign and malignant marrow abnormalities for both readers (P < 0.001). SIb-800 and perfusion-related parameters from IVIM-DWI and DCE were not significantly different between the two groups (P = 0.145, 0.439, and 0.337 for reader 1, P = 0.378, 0.368, and 0.343 for reader 2, respectively). The AUCs of ADC, Dslow, and Ff were significantly higher for differentiating indeterminate marrow abnormalities in both readers (P < 0.001). Interobserver agreements were substantial in SIb-800, and ICCs were almost perfect for ADC, Dslow, f, and Ff, and substantial for iAUC, kep, Ktrans, ve, and Dfast. Conclusion: ADC, Dslow, and Ff may provide information for differentiating focal indeterminate abnormalities. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:49–60.",

keywords = "bone marrow, chemical shift, dynamic contrast-enhanced imaging, intravoxel incoherent motion",

author = "Baik, \{Jun Seung\} and Jung, \{Joon Yong\} and Jee, \{Won Hee\} and Chun, \{Chang Woo\} and Kim, \{Sun Ki\} and Shin, \{Seung Han\} and Chung, \{Yang Guk\} and Jung, \{Chan Kwon\} and Stephan Kannengiesser and Sohn, \{Yo Han\}",

note = "Publisher Copyright: {\textcopyright} 2016 International Society for Magnetic Resonance in Medicine",

year = "2017",

month = jul,

doi = "10.1002/jmri.25536",

language = "English",

volume = "46",

pages = "49--60",

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TY - JOUR

T1 - Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI

AU - Baik, Jun Seung

AU - Jung, Joon Yong

AU - Jee, Won Hee

AU - Chun, Chang Woo

AU - Kim, Sun Ki

AU - Shin, Seung Han

AU - Chung, Yang Guk

AU - Jung, Chan Kwon

AU - Kannengiesser, Stephan

AU - Sohn, Yo Han

PY - 2017/7

Y1 - 2017/7

N2 - Purpose: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities. Materials and Methods: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast, and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, Ktrans, kep, and ve). The MR characteristics and parameters from benign and malignant lesions were compared with a chi-squared test and the Mann–Whitney U-test, respectively. The area under receiver operating characteristic (ROC) curves (AUC) of each sequence were also compared. Interobserver agreements were assessed with Cohen's κ, and intraclass correlation coefficient (ICC). Results: ADC, Dslow, and Ff demonstrated a significant difference between benign and malignant marrow abnormalities for both readers (P < 0.001). SIb-800 and perfusion-related parameters from IVIM-DWI and DCE were not significantly different between the two groups (P = 0.145, 0.439, and 0.337 for reader 1, P = 0.378, 0.368, and 0.343 for reader 2, respectively). The AUCs of ADC, Dslow, and Ff were significantly higher for differentiating indeterminate marrow abnormalities in both readers (P < 0.001). Interobserver agreements were substantial in SIb-800, and ICCs were almost perfect for ADC, Dslow, f, and Ff, and substantial for iAUC, kep, Ktrans, ve, and Dfast. Conclusion: ADC, Dslow, and Ff may provide information for differentiating focal indeterminate abnormalities. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:49–60.

AB - Purpose: To explore magnetic resonance imaging (MRI) parameters from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), multiecho Dixon imaging (ME-Dixon), and dynamic contrast-enhanced imaging (DCE) for differentiating focal indeterminate marrow abnormalities. Materials and Methods: Forty-two patients with 14 benign and 28 malignant focal marrow abnormalities were included. The following were independently analyzed by two readers: signal intensity (SI), contour, and margin on conventional MR images; SI on b-800 images (SIb-800), apparent diffusion coefficient (ADC), IVIM parameters (Dslow, Dfast, and f), fat fraction (Ff), and DCE parameters (time-to-signal intensity curve pattern, iAUC, Ktrans, kep, and ve). The MR characteristics and parameters from benign and malignant lesions were compared with a chi-squared test and the Mann–Whitney U-test, respectively. The area under receiver operating characteristic (ROC) curves (AUC) of each sequence were also compared. Interobserver agreements were assessed with Cohen's κ, and intraclass correlation coefficient (ICC). Results: ADC, Dslow, and Ff demonstrated a significant difference between benign and malignant marrow abnormalities for both readers (P < 0.001). SIb-800 and perfusion-related parameters from IVIM-DWI and DCE were not significantly different between the two groups (P = 0.145, 0.439, and 0.337 for reader 1, P = 0.378, 0.368, and 0.343 for reader 2, respectively). The AUCs of ADC, Dslow, and Ff were significantly higher for differentiating indeterminate marrow abnormalities in both readers (P < 0.001). Interobserver agreements were substantial in SIb-800, and ICCs were almost perfect for ADC, Dslow, f, and Ff, and substantial for iAUC, kep, Ktrans, ve, and Dfast. Conclusion: ADC, Dslow, and Ff may provide information for differentiating focal indeterminate abnormalities. Level of Evidence: 3. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:49–60.

KW - bone marrow

KW - chemical shift

KW - dynamic contrast-enhanced imaging

KW - intravoxel incoherent motion

UR - https://www.scopus.com/pages/publications/85000796431

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DO - 10.1002/jmri.25536

M3 - Article

C2 - 27859835

AN - SCOPUS:85000796431

SN - 1053-1807

VL - 46

SP - 49

EP - 60

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 1

ER -

Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI

Abstract

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Keywords

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