Abstract
The field of tissue regeneration has seen a paradigm shift after one wave of technological innovation after another, which has notably made significant contributions to basic cellular response control and overall tissue regeneration. One particular area that is seeing rekindled interest after technological innovation is managing cell migration toward defects because successful host cell migration from adjacent tissue can accelerate overall regeneration time in tissue defects that are either large in size or irregular in shape. This chapter surveys significant advances on directed cell migration upon topological cues. First, we introduce several examples of patterning and electrospinning technology for guiding directed cell migration, followed by a discussion on approaches to influencing radially aligned topography in pattern or electrospun sheet for overall tissue regeneration.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer |
| Pages | 131-140 |
| Number of pages | 10 |
| DOIs | |
| State | Published - 2020 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1249 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
Bibliographical note
Funding Information:This work was supported by a grant from the National Research Foundation (NRF) of Korea, which is supported by the Korean government (MEST) (NRF-2017R1D1A1B03031656 to Y.M.S.), and a grant from the Ministry of Trade, Industry and Energy (MOTIE) (Grant No. 10047811 to H.J.C).
Publisher Copyright:
© 2020, Springer Nature Singapore Pte Ltd.
Keywords
- Cell migration
- Contact guidance
- Electrospinning
- Patterning
- Radially aligned
- Topographical cue