Abstract
Purpose: To determine whether the frequencies of specific killer cell immunoglobulin-like receptors (KIR) genotypes are associated with the incidence of uveitis in ankylosing spondylitis (AS) and Behçet disease (BD). Methods: The authors analyzed the frequency of 16 KIR genes in Koreans with either AS (110 patients, all HLA-B27-positive) or BD (86 patients), using polymerase chain reaction sequence-specific oligonucleotide probing. Results: The frequency of the inhibitory receptor KIR3DL1 was lower in AS patients affected by uveitis than that in the general population (p < 0.05). The frequency of the KIR3DL1-/2DS3- was significantly higher in AS patients with uveitis (odds ratio = 9.306, p = 0.007). Conclusions: The study suggests that KIR3DL1 might associate with the resistance to AS-associated uveitis by influencing natural killer cell activity.
| Original language | English |
|---|---|
| Pages (from-to) | 135-143 |
| Number of pages | 9 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2013 |
Bibliographical note
Funding Information:This research was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A092258).
Keywords
- Ankylosing spondylitis
- Behçet disease
- KIR
- KIR genotype
- Uveitis