DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee; Hwa Young Lee; Changsu Han; Chi Un Pae; Woo Suk Tae; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Byung Joo Ham

doi:10.1016/j.bbr.2011.04.007

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee, Hwa Young Lee, Changsu Han, Chi Un Pae, Woo Suk Tae, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Byung Joo Ham

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	Behavioural Brain Research
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2011.04.007
State	Published - 30 Sep 2011

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).

Keywords

Dopamine receptor D2
FMRI
Polymorphism
Striatum

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10.1016/j.bbr.2011.04.007

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title = "DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli",

abstract = "DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.",

keywords = "Dopamine receptor D2, FMRI, Polymorphism, Striatum",

author = "Lee, {Byeong Taek} and Lee, {Hwa Young} and Changsu Han and Pae, {Chi Un} and Tae, {Woo Suk} and Lee, {Min Soo} and Joe, {Sook Haeng} and Jung, {In Kwa} and Ham, {Byung Joo}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).",

year = "2011",

month = sep,

day = "30",

doi = "10.1016/j.bbr.2011.04.007",

language = "English",

volume = "223",

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journal = "Behavioural Brain Research",

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T1 - DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

AU - Lee, Byeong Taek

AU - Lee, Hwa Young

AU - Han, Changsu

AU - Pae, Chi Un

AU - Tae, Woo Suk

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Ham, Byung Joo

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).

PY - 2011/9/30

Y1 - 2011/9/30

N2 - DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

AB - DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

KW - Dopamine receptor D2

KW - FMRI

KW - Polymorphism

KW - Striatum

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DO - 10.1016/j.bbr.2011.04.007

M3 - Article

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SN - 0166-4328

VL - 223

SP - 36

EP - 41

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Abstract

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Keywords

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