DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee; Hwa Young Lee; Changsu Han; Chi Un Pae; Woo Suk Tae; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Byung Joo Ham

doi:10.1016/j.bbr.2011.04.007

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Byeong Taek Lee
, Hwa Young Lee
, Changsu Han
, Chi Un Pae
, Woo Suk Tae
, Min Soo Lee
, Sook Haeng Joe
, In Kwa Jung
, Byung Joo Ham

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

Original language	English
Pages (from-to)	36-41
Number of pages	6
Journal	Behavioural Brain Research
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2011.04.007
State	Published - 30 Sep 2011

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).

Keywords

Dopamine receptor D2
FMRI
Polymorphism
Striatum

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10.1016/j.bbr.2011.04.007

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@article{cf93feaad6c3465da92f446b5e6b578c,

title = "DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli",

abstract = "DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.",

keywords = "Dopamine receptor D2, FMRI, Polymorphism, Striatum",

author = "Lee, \{Byeong Taek\} and Lee, \{Hwa Young\} and Changsu Han and Pae, \{Chi Un\} and Tae, \{Woo Suk\} and Lee, \{Min Soo\} and Joe, \{Sook Haeng\} and Jung, \{In Kwa\} and Ham, \{Byung Joo\}",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).",

year = "2011",

month = sep,

day = "30",

doi = "10.1016/j.bbr.2011.04.007",

language = "English",

volume = "223",

pages = "36--41",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier B.V.",

number = "1",

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TY - JOUR

T1 - DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

AU - Lee, Byeong Taek

AU - Lee, Hwa Young

AU - Han, Changsu

AU - Pae, Chi Un

AU - Tae, Woo Suk

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Ham, Byung Joo

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-2008-313-E00330 ).

PY - 2011/9/30

Y1 - 2011/9/30

N2 - DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

AB - DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1 TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1 TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1 TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.

KW - Dopamine receptor D2

KW - FMRI

KW - Polymorphism

KW - Striatum

UR - https://www.scopus.com/pages/publications/79955823507

U2 - 10.1016/j.bbr.2011.04.007

DO - 10.1016/j.bbr.2011.04.007

M3 - Article

C2 - 21510979

AN - SCOPUS:79955823507

SN - 0166-4328

VL - 223

SP - 36

EP - 41

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 1

ER -

DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli

Abstract

Bibliographical note

Keywords

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