Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Yoon Kyung Kwon; Soo Jung Choi; Cho Rong Kim; Jae Kyeom Kim; Hye Kyung Kim; Jong Hun Choi; Sang Wook Song; Chang Ju Kim; Gwi Gun Park; Cheung Seog Park; Dong Hoon Shin

doi:10.1248/cpb.c15-00559

Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Yoon Kyung Kwon, Soo Jung Choi, Cho Rong Kim, Jae Kyeom Kim, Hye Kyung Kim, Jong Hun Choi, Sang Wook Song, Chang Ju Kim, Gwi Gun Park, Cheung Seog Park, Dong Hoon Shin

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [¹⁴C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.

Original language	English
Pages (from-to)	1076-1080
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	12
DOIs	https://doi.org/10.1248/cpb.c15-00559
State	Published - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 The Pharmaceutical Society of Japan.

Keywords

Chaenomeles sinensis
Choline acetyltransferase
Cognitive impairment
Learning
Memory
Stearic acid methyl ester

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kwon, Y. K., Choi, S. J., Kim, C. R., Kim, J. K., Kim, H. K., Choi, J. H., Song, S. W., Kim, C. J., Park, G. G., Park, C. S., & Shin, D. H. (2015). Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice. Chemical and Pharmaceutical Bulletin, 63(12), 1076-1080. https://doi.org/10.1248/cpb.c15-00559

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abstract = "The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [14C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.",

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doi = "10.1248/cpb.c15-00559",

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AU - Kwon, Yoon Kyung

AU - Choi, Soo Jung

AU - Kim, Cho Rong

AU - Kim, Jae Kyeom

AU - Kim, Hye Kyung

AU - Choi, Jong Hun

AU - Song, Sang Wook

AU - Kim, Chang Ju

AU - Park, Gwi Gun

AU - Park, Cheung Seog

AU - Shin, Dong Hoon

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AB - The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [14C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.

KW - Chaenomeles sinensis

KW - Choline acetyltransferase

KW - Cognitive impairment

KW - Learning

KW - Memory

KW - Stearic acid methyl ester

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JO - Chemical and Pharmaceutical Bulletin

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ER -

Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Abstract

Bibliographical note

Keywords

UN SDGs

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