Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Yoon Kyung Kwon; Soo Jung Choi; Cho Rong Kim; Jae Kyeom Kim; Hye Kyung Kim; Jong Hun Choi; Sang Wook Song; Chang Ju Kim; Gwi Gun Park; Cheung Seog Park; Dong Hoon Shin

doi:10.1248/cpb.c15-00559

Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Yoon Kyung Kwon
, Soo Jung Choi
, Cho Rong Kim
, Jae Kyeom Kim
, Hye Kyung Kim
, Jong Hun Choi
, Sang Wook Song
, Chang Ju Kim
, Gwi Gun Park
, Cheung Seog Park
, Dong Hoon Shin

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [¹⁴C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.

Original language	English
Pages (from-to)	1076-1080
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	12
DOIs	https://doi.org/10.1248/cpb.c15-00559
State	Published - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 The Pharmaceutical Society of Japan.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chaenomeles sinensis
Choline acetyltransferase
Cognitive impairment
Learning
Memory
Stearic acid methyl ester

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10.1248/cpb.c15-00559

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Kwon, Y. K., Choi, S. J., Kim, C. R., Kim, J. K., Kim, H. K., Choi, J. H., Song, S. W., Kim, C. J., Park, G. G., Park, C. S., & Shin, D. H. (2015). Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice. Chemical and Pharmaceutical Bulletin, 63(12), 1076-1080. https://doi.org/10.1248/cpb.c15-00559

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abstract = "The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [14C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.",

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doi = "10.1248/cpb.c15-00559",

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AU - Kwon, Yoon Kyung

AU - Choi, Soo Jung

AU - Kim, Cho Rong

AU - Kim, Jae Kyeom

AU - Kim, Hye Kyung

AU - Choi, Jong Hun

AU - Song, Sang Wook

AU - Kim, Chang Ju

AU - Park, Gwi Gun

AU - Park, Cheung Seog

AU - Shin, Dong Hoon

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AB - The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis KOEHNE showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [14C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.

KW - Chaenomeles sinensis

KW - Choline acetyltransferase

KW - Cognitive impairment

KW - Learning

KW - Memory

KW - Stearic acid methyl ester

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DO - 10.1248/cpb.c15-00559

M3 - Article

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AN - SCOPUS:84955503065

SN - 0009-2363

VL - 63

SP - 1076

EP - 1080

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 12

ER -

Effect of chaenomeles sinensis extract on choline acetyltransferase activity and trimethyltin-induced learning and memory impairment in mice

Abstract

Bibliographical note

UN SDGs

Keywords

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