Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.

C. Y. Yoon; C. M. Hong; J. Y. Song; Y. Y. Cho; K. S. Choi; B. J. Lee; C. K. Kim

doi:10.4142/jvs.2001.2.1.47

Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.

C. Y. Yoon
, C. M. Hong
, J. Y. Song
, Y. Y. Cho
, K. S. Choi
, B. J. Lee
, C. K. Kim

Food and Drug Administration of Korea

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric method. A total of 50 rats (in number, 25 pubertal and 25 adult rats) was divided into 5 experimental groups including 0 (control), 50, 100, 200, and 400 mg EGEE/kg of body weight. The animals were administered by gavage for 4 weeks. In adult rats, the treatment of EGEE at the dose of 400 mg/kg of body weight decreased significantly the populations of haploid, while it increased those of diploid and tetraploid cells. In pubertal rats, the treatment of EGEE at the dose of 400 mg/kg of body weight caused only minimal changes in the relative percent of testicular cell types. These results suggest that the effects of EGEE on testicular function in pubertal rats appear to be less pronounced than in adult rats.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Journal of Veterinary Science
Volume	2
Issue number	1
DOIs	https://doi.org/10.4142/jvs.2001.2.1.47
State	Published - Apr 2001

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title = "Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.",

abstract = "The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric method. A total of 50 rats (in number, 25 pubertal and 25 adult rats) was divided into 5 experimental groups including 0 (control), 50, 100, 200, and 400 mg EGEE/kg of body weight. The animals were administered by gavage for 4 weeks. In adult rats, the treatment of EGEE at the dose of 400 mg/kg of body weight decreased significantly the populations of haploid, while it increased those of diploid and tetraploid cells. In pubertal rats, the treatment of EGEE at the dose of 400 mg/kg of body weight caused only minimal changes in the relative percent of testicular cell types. These results suggest that the effects of EGEE on testicular function in pubertal rats appear to be less pronounced than in adult rats.",

author = "Yoon, \{C. Y.\} and Hong, \{C. M.\} and Song, \{J. Y.\} and Cho, \{Y. Y.\} and Choi, \{K. S.\} and Lee, \{B. J.\} and Kim, \{C. K.\}",

year = "2001",

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doi = "10.4142/jvs.2001.2.1.47",

language = "English",

volume = "2",

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TY - JOUR

T1 - Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.

AU - Yoon, C. Y.

AU - Hong, C. M.

AU - Song, J. Y.

AU - Cho, Y. Y.

AU - Choi, K. S.

AU - Lee, B. J.

AU - Kim, C. K.

PY - 2001/4

Y1 - 2001/4

N2 - The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric method. A total of 50 rats (in number, 25 pubertal and 25 adult rats) was divided into 5 experimental groups including 0 (control), 50, 100, 200, and 400 mg EGEE/kg of body weight. The animals were administered by gavage for 4 weeks. In adult rats, the treatment of EGEE at the dose of 400 mg/kg of body weight decreased significantly the populations of haploid, while it increased those of diploid and tetraploid cells. In pubertal rats, the treatment of EGEE at the dose of 400 mg/kg of body weight caused only minimal changes in the relative percent of testicular cell types. These results suggest that the effects of EGEE on testicular function in pubertal rats appear to be less pronounced than in adult rats.

AB - The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric method. A total of 50 rats (in number, 25 pubertal and 25 adult rats) was divided into 5 experimental groups including 0 (control), 50, 100, 200, and 400 mg EGEE/kg of body weight. The animals were administered by gavage for 4 weeks. In adult rats, the treatment of EGEE at the dose of 400 mg/kg of body weight decreased significantly the populations of haploid, while it increased those of diploid and tetraploid cells. In pubertal rats, the treatment of EGEE at the dose of 400 mg/kg of body weight caused only minimal changes in the relative percent of testicular cell types. These results suggest that the effects of EGEE on testicular function in pubertal rats appear to be less pronounced than in adult rats.

UR - https://www.scopus.com/pages/publications/0642311585

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DO - 10.4142/jvs.2001.2.1.47

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SP - 47

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JF - Journal of Veterinary Science

IS - 1

ER -

Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.

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