Abstract
PURPOSE: The purpose of this multi-institute, single-group clinical trial was to evaluate the effectiveness and safety of toric orthokeratology lenses for the treatment of patients with combined myopia and astigmatism.
METHODS: A total of 44 patients were included in this clinical trial. The patients ranged in age from 7 to 49 years, with myopia of -0.75 to -6.0 diopters (D) and astigmatism of 1.25 to 4.0 D. After excluding 21 subjects, 23 subjects (39 eyes) were analyzed after toric orthokeratology lens use. The subjects underwent ophthalmologic examination after 1 day and 1, 2, 3, and 4 weeks of wearing overnight toric orthokeratology lenses.
RESULTS: A total of 19 subjects (31 eyes) completed the trial after five subjects (eight eyes) dropped out. In the patients who completed the study by wearing lenses for 4 weeks, the myopic refractive error decreased significantly by 2.60 ± 2.21 D (p < 0.001), from -3.65 ± 1.62 to -1.05 ± 1.64 D. The astigmatic refractive error were also significantly decreased by 0.63 ± 0.98 D (p = 0.001), from 2.07 ± 0.83 to 1.44 ± 0.99 D. The mean uncorrected and corrected visual acuities before wearing the lenses were 2.14 ± 0.80 logarithm of the logMAR (logMAR) and 0.05 ± 0.13 logMAR, respectively, which changed to 0.12 ± 0.30 logarithm of the logMAR (p < 0.001) and 0.01 ± 0.04 logMAR (p = 0.156) after 4 weeks. No serious adverse reactions were reported during the clinical trial.
CONCLUSIONS: Our results suggest that toric orthokeratology is an effective and safe treatment for correcting visual acuity in patients with combined myopia and astigmatism.
| Original language | English |
|---|---|
| Pages (from-to) | 434-442 |
| Number of pages | 9 |
| Journal | Korean journal of ophthalmology : KJO |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Dec 2016 |
Bibliographical note
Funding Information:There was no external funding in the preparation of this manuscript. Internal funding provided by the American Society of Interventional Pain Physicians (ASIPP) was limited to travel and lodging expenses of the authors.
Funding Information:
contradictory evidence with lack of effectiveness (507-516). These reports have been extensively criticized for their inappropriate analysis, confluence of interest, and finally, inappropriate classification of local anesthetics as placebo agents (415,416,487-491,511-514). However, the studies performed abroad supported by governmental funding (520-522) from the National Health Services (NHS) and Health Technology Assessment (HTA) program have presented positive results for epidural injections, in contrast to AHRQ-sponsored studies (520,521). In NHS and HTA sponsored studies, Lewis et al (513-520) showed the effectiveness of epidural corticosteroid injections. They (521) also showed the superiority of epidural injections to traction, percutaneous discectomy, and exercise therapy. Evidence based on best evidence synthesis ranged from Level II to III in managing multiple pathologies in the lumbar, cervical, and thoracic spine.
Keywords
- Astigmatism
- Contact lenses
- Myopia
- Orthokeratologic procedures
- Refraction