Effects of joint effusion on proprioception in patients with knee osteoarthritis: A single-blind, randomized controlled clinical trial

Objective: To assess the effects of joint effusion on proprioceptive status in patients with knee osteoarthritis (OA). Design: A single-blind, randomized, controlled clinical trial in 40 female subjects aged 50 years and over with painful knee OA. All subjects were randomly assigned to either the control or experimental group. A volume of 20. mL of normal saline was injected into the knee joint cavity of subjects in the experimental group under ultrasonographic guidance. Proprioceptive acuity was assessed by active repositioning of the lower limb using an electrogoniometer to measure knee joint position sense (JPS) under both non-weight-bearing (NWB) and weight-bearing (WB) conditions twice, with a 20-min rest interval. The experimental group performed the task twice (Test 1 and Test 2) before and within 5. min after joint infusion. The control group also performed Test 1 and Test 2 without joint infusion. The outcome of interest was the absolute angular error (AAE), ignoring the direction of the error, between the randomized target angle and the patient's reproduced angle of JPS values. Results: Compared with the control group, JPS was significantly compromised in the experimental group in the NWB test after joint infusion (P= 0.025). However, no significant differences in the angular error were observed between Test 1 and Test 2 in the control group for the NWB or WB test or in the experimental group for the WB test after infusion (P> 0.05). Conclusions: This study showed that joint effusion impairs proprioceptive function in osteoarthritic knee joints. Clinical trial number: NCT01060215 (ClinicalTrials.gov Identifier).