Effects of mirtazapine in patients with post-traumatic stress disorder in Korea: A pilot study

Won Myong Bahk; Chi Un Pae; Joshua Tsoh; Jeong Ho Chae; Tae Youn Jun; Chul-Lee; Kwang Soo Kim

doi:10.1002/hup.426

Effects of mirtazapine in patients with post-traumatic stress disorder in Korea: A pilot study

Won Myong Bahk
, Chi Un Pae
, Joshua Tsoh
, Jeong Ho Chae
, Tae Youn Jun
, Chul-Lee
, Kwang Soo Kim

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

This study was aimed at testing the efficacy and tolerability of mirtazapine in the treatment of Korean patients with chronic post-traumatic stress disorder (PTSD). Mirtazapine was administered for 8 weeks using a flexible-dose regime in 15 Korean patients with PTSD based on the DSM-IV criteria. We evaluated the patients at baseline and at weeks 4 and 8 after treatment with the interviewer-administered structured interview for PTSD (SIP), short PTSD rating interview (SPRINT), impact of event scale-revised (IES-R) and the Montgomery Åsberg depression rating scale (MADRS). Scores on the SIP, SPRINT, IES-R and MADRS had significantly reduced after 8 weeks treatment. In this pilot study, mirtazapine was found to be effective and well tolerated in the treatment of patients with PTSD. This calls for further evaluation of the effect of this drug on subjects with PTSD with randomized placebo-controlled studies.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Human Psychopharmacology
Volume	17
Issue number	7
DOIs	https://doi.org/10.1002/hup.426
State	Published - Oct 2002

Keywords

Korea
Mirtazapine
PTSD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hup.426

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title = "Effects of mirtazapine in patients with post-traumatic stress disorder in Korea: A pilot study",

abstract = "This study was aimed at testing the efficacy and tolerability of mirtazapine in the treatment of Korean patients with chronic post-traumatic stress disorder (PTSD). Mirtazapine was administered for 8 weeks using a flexible-dose regime in 15 Korean patients with PTSD based on the DSM-IV criteria. We evaluated the patients at baseline and at weeks 4 and 8 after treatment with the interviewer-administered structured interview for PTSD (SIP), short PTSD rating interview (SPRINT), impact of event scale-revised (IES-R) and the Montgomery {\AA}sberg depression rating scale (MADRS). Scores on the SIP, SPRINT, IES-R and MADRS had significantly reduced after 8 weeks treatment. In this pilot study, mirtazapine was found to be effective and well tolerated in the treatment of patients with PTSD. This calls for further evaluation of the effect of this drug on subjects with PTSD with randomized placebo-controlled studies.",

keywords = "Korea, Mirtazapine, PTSD",

author = "Bahk, \{Won Myong\} and Pae, \{Chi Un\} and Joshua Tsoh and Chae, \{Jeong Ho\} and Jun, \{Tae Youn\} and Chul-Lee and Kim, \{Kwang Soo\}",

year = "2002",

month = oct,

doi = "10.1002/hup.426",

language = "English",

volume = "17",

pages = "341--344",

journal = "Human Psychopharmacology",

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T2 - A pilot study

AU - Bahk, Won Myong

AU - Pae, Chi Un

AU - Tsoh, Joshua

AU - Chae, Jeong Ho

AU - Jun, Tae Youn

AU - Chul-Lee,

AU - Kim, Kwang Soo

PY - 2002/10

Y1 - 2002/10

N2 - This study was aimed at testing the efficacy and tolerability of mirtazapine in the treatment of Korean patients with chronic post-traumatic stress disorder (PTSD). Mirtazapine was administered for 8 weeks using a flexible-dose regime in 15 Korean patients with PTSD based on the DSM-IV criteria. We evaluated the patients at baseline and at weeks 4 and 8 after treatment with the interviewer-administered structured interview for PTSD (SIP), short PTSD rating interview (SPRINT), impact of event scale-revised (IES-R) and the Montgomery Åsberg depression rating scale (MADRS). Scores on the SIP, SPRINT, IES-R and MADRS had significantly reduced after 8 weeks treatment. In this pilot study, mirtazapine was found to be effective and well tolerated in the treatment of patients with PTSD. This calls for further evaluation of the effect of this drug on subjects with PTSD with randomized placebo-controlled studies.

AB - This study was aimed at testing the efficacy and tolerability of mirtazapine in the treatment of Korean patients with chronic post-traumatic stress disorder (PTSD). Mirtazapine was administered for 8 weeks using a flexible-dose regime in 15 Korean patients with PTSD based on the DSM-IV criteria. We evaluated the patients at baseline and at weeks 4 and 8 after treatment with the interviewer-administered structured interview for PTSD (SIP), short PTSD rating interview (SPRINT), impact of event scale-revised (IES-R) and the Montgomery Åsberg depression rating scale (MADRS). Scores on the SIP, SPRINT, IES-R and MADRS had significantly reduced after 8 weeks treatment. In this pilot study, mirtazapine was found to be effective and well tolerated in the treatment of patients with PTSD. This calls for further evaluation of the effect of this drug on subjects with PTSD with randomized placebo-controlled studies.

KW - Korea

KW - Mirtazapine

KW - PTSD

UR - https://www.scopus.com/pages/publications/0036798078

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JO - Human Psychopharmacology

JF - Human Psychopharmacology

IS - 7

ER -

Effects of mirtazapine in patients with post-traumatic stress disorder in Korea: A pilot study

Abstract

Keywords

UN SDGs

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