Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism

Mee Kyoung Kim; Hyuk Sang Kwon; Ki Hyun Baek; Je Hoon Lee; Woo Chan Park; Hyung Sun Sohn; Kwang Woo Lee; Ki Ho Song

doi:10.2337/dc10-0988

Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

OBJECTIVE - We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. RESEARCH DESIGN AND METHODS - A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. RESULTS - A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. CONCLUSIONS - Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.

Original language	English
Pages (from-to)	2546-2548
Number of pages	3
Journal	Diabetes Care
Volume	33
Issue number	12
DOIs	https://doi.org/10.2337/dc10-0988
State	Published - Dec 2010

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@article{0971f269286e43e8b91ab8ff5d855898,

title = "Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism",

abstract = "OBJECTIVE - We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. RESEARCH DESIGN AND METHODS - A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. RESULTS - A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. CONCLUSIONS - Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.",

author = "Kim, \{Mee Kyoung\} and Kwon, \{Hyuk Sang\} and Baek, \{Ki Hyun\} and Lee, \{Je Hoon\} and Park, \{Woo Chan\} and Sohn, \{Hyung Sun\} and Lee, \{Kwang Woo\} and Song, \{Ki Ho\}",

year = "2010",

month = dec,

doi = "10.2337/dc10-0988",

language = "English",

volume = "33",

pages = "2546--2548",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association Inc.",

number = "12",

}

TY - JOUR

T1 - Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism

AU - Kim, Mee Kyoung

AU - Kwon, Hyuk Sang

AU - Baek, Ki Hyun

AU - Lee, Je Hoon

AU - Park, Woo Chan

AU - Sohn, Hyung Sun

AU - Lee, Kwang Woo

AU - Song, Ki Ho

PY - 2010/12

Y1 - 2010/12

N2 - OBJECTIVE - We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. RESEARCH DESIGN AND METHODS - A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. RESULTS - A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. CONCLUSIONS - Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.

AB - OBJECTIVE - We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism. RESEARCH DESIGN AND METHODS - A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement. RESULTS - A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered. CONCLUSIONS - Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.

UR - https://www.scopus.com/pages/publications/79951692416

U2 - 10.2337/dc10-0988

DO - 10.2337/dc10-0988

M3 - Article

C2 - 20823345

AN - SCOPUS:79951692416

SN - 1935-5548

VL - 33

SP - 2546

EP - 2548

JO - Diabetes Care

JF - Diabetes Care

IS - 12

ER -

Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism

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