Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma

Byung Joon Chun; Ie Ryung Yoo; Young Hoon Joo; Inn Chul Nam; Jung Hae Cho; Choung Soo Kim; Kwang Jae Cho; Min Sik Kim

doi:10.1002/hed.23889

Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma

Byung Joon Chun
, Ie Ryung Yoo
, Young Hoon Joo
, Inn Chul Nam
, Jung Hae Cho
, Choung Soo Kim
, Kwang Jae Cho
, Min Sik Kim

Department of Otorhinolaryngology

Catholic Univ. of Korea Coll. Med.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background We evaluated the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. Methods We reviewed the medical records of 89 patients with laryngeal cancer who underwent FDG PET/CT before surgery. Results ECS was present in 38.2% (18 of 47) of dissected necks and in 32.2% (20 of 62) of dissected cervical levels. There was a significant difference in the standardized uptake value maximum (SUV_max) between cervical lymph nodes with and without ECS (6.39 ± 4.53 vs 1.21 ± 1.70; p <.001); the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7% and specificity of 85.6%. Conclusion A median SUV_max cutoff value >2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer.

Original language	English
Pages (from-to)	290-293
Number of pages	4
Journal	Head and Neck
Volume	38
Issue number	2
DOIs	https://doi.org/10.1002/hed.23889
State	Published - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc. Head Neck 38: 290-293, 2016 © 2014 Wiley Periodicals, Inc.

Keywords

extracapsular spread
larynx
lymphatic metastasis
positron emission tomography
squamous cell carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.23889

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@article{b7176a996fc444b0a0d92afdba485145,

title = "Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma",

abstract = "Background We evaluated the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. Methods We reviewed the medical records of 89 patients with laryngeal cancer who underwent FDG PET/CT before surgery. Results ECS was present in 38.2\% (18 of 47) of dissected necks and in 32.2\% (20 of 62) of dissected cervical levels. There was a significant difference in the standardized uptake value maximum (SUVmax) between cervical lymph nodes with and without ECS (6.39 ± 4.53 vs 1.21 ± 1.70; p <.001); the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7\% and specificity of 85.6\%. Conclusion A median SUVmax cutoff value >2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer.",

keywords = "extracapsular spread, larynx, lymphatic metastasis, positron emission tomography, squamous cell carcinoma",

author = "Chun, \{Byung Joon\} and Yoo, \{Ie Ryung\} and Joo, \{Young Hoon\} and Nam, \{Inn Chul\} and Cho, \{Jung Hae\} and Kim, \{Choung Soo\} and Cho, \{Kwang Jae\} and Kim, \{Min Sik\}",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley Periodicals, Inc. Head Neck 38: 290-293, 2016 {\textcopyright} 2014 Wiley Periodicals, Inc.",

year = "2016",

month = feb,

day = "1",

doi = "10.1002/hed.23889",

language = "English",

volume = "38",

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journal = "Head and Neck",

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TY - JOUR

T1 - Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma

AU - Chun, Byung Joon

AU - Yoo, Ie Ryung

AU - Joo, Young Hoon

AU - Nam, Inn Chul

AU - Cho, Jung Hae

AU - Kim, Choung Soo

AU - Cho, Kwang Jae

AU - Kim, Min Sik

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background We evaluated the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. Methods We reviewed the medical records of 89 patients with laryngeal cancer who underwent FDG PET/CT before surgery. Results ECS was present in 38.2% (18 of 47) of dissected necks and in 32.2% (20 of 62) of dissected cervical levels. There was a significant difference in the standardized uptake value maximum (SUVmax) between cervical lymph nodes with and without ECS (6.39 ± 4.53 vs 1.21 ± 1.70; p <.001); the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7% and specificity of 85.6%. Conclusion A median SUVmax cutoff value >2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer.

AB - Background We evaluated the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. Methods We reviewed the medical records of 89 patients with laryngeal cancer who underwent FDG PET/CT before surgery. Results ECS was present in 38.2% (18 of 47) of dissected necks and in 32.2% (20 of 62) of dissected cervical levels. There was a significant difference in the standardized uptake value maximum (SUVmax) between cervical lymph nodes with and without ECS (6.39 ± 4.53 vs 1.21 ± 1.70; p <.001); the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7% and specificity of 85.6%. Conclusion A median SUVmax cutoff value >2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer.

KW - extracapsular spread

KW - larynx

KW - lymphatic metastasis

KW - positron emission tomography

KW - squamous cell carcinoma

UR - https://www.scopus.com/pages/publications/84955715299

U2 - 10.1002/hed.23889

DO - 10.1002/hed.23889

M3 - Article

C2 - 25327765

AN - SCOPUS:84955715299

SN - 1043-3074

VL - 38

SP - 290

EP - 293

JO - Head and Neck

JF - Head and Neck

IS - 2

ER -

Efficacy of 18F-fluorodeoxyglucose positron emission tomography/CT imaging for extracapsular spread of laryngeal squamous cell carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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