Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction

Manho Kim; Min Wook Kim; You Chul Chung; Hee Chan Jung; Moon Seo Park; Young Min Han; Yong An Chung; Lee So Maeng; Sang In Park; Jiyeon Lim; Woo Seok Im; Jin Young Chung; Minky Kim; Inhee Mook

doi:10.1136/acupmed-2011-010126

Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction

Manho Kim, Min Wook Kim, You Chul Chung, Hee Chan Jung, Moon Seo Park, Young Min Han, Yong An Chung, Lee So Maeng, Sang In Park, Jiyeon Lim, Woo Seok Im, Jin Young Chung, Minky Kim, Inhee Mook

Department of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Objective Electroacupuncture (EA) is a traditional medicine in patients with post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery. Methods Occlusion of the middle cerebral artery was performed in rats (N=12) followed by reperfusion. EA was applied at the GV20 (Baihui) acupoint. Motor and sensory functions were monitored on the Garcia scale for 2 weeks. Expressions of BDNF and receptor tyrosine kinase B (trkB) were determined by immunoblotting and immunohistochemistry. Results Improvement of Garcia scores, particularly in motor performance, were noted in the group with EA stimulation (p<0.05). With EA application, BDNF was elevated in the ischaemic hemisphere with increased numbers of BDNF(+) cells. Increased expression of trkB was also detected. Conclusion These results indicate that EA at GV20 improves motor recovery and stimulates BDNF/trkB expression in rats with cerebral ischaemia.

Original language	English
Pages (from-to)	222-226
Number of pages	5
Journal	Acupuncture in Medicine
Volume	30
Issue number	3
DOIs	https://doi.org/10.1136/acupmed-2011-010126
State	Published - Sep 2012

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Kim, M., Kim, M. W., Chung, Y. C., Jung, H. C., Park, M. S., Han, Y. M., Chung, Y. A., Maeng, L. S., Park, S. I., Lim, J., Im, W. S., Chung, J. Y., Kim, M., & Mook, I. (2012). Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction. Acupuncture in Medicine, 30(3), 222-226. https://doi.org/10.1136/acupmed-2011-010126

@article{7319e18b1582441ba06e9b07cc39a0c7,

title = "Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction",

abstract = "Objective Electroacupuncture (EA) is a traditional medicine in patients with post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery. Methods Occlusion of the middle cerebral artery was performed in rats (N=12) followed by reperfusion. EA was applied at the GV20 (Baihui) acupoint. Motor and sensory functions were monitored on the Garcia scale for 2 weeks. Expressions of BDNF and receptor tyrosine kinase B (trkB) were determined by immunoblotting and immunohistochemistry. Results Improvement of Garcia scores, particularly in motor performance, were noted in the group with EA stimulation (p<0.05). With EA application, BDNF was elevated in the ischaemic hemisphere with increased numbers of BDNF(+) cells. Increased expression of trkB was also detected. Conclusion These results indicate that EA at GV20 improves motor recovery and stimulates BDNF/trkB expression in rats with cerebral ischaemia.",

author = "Manho Kim and Kim, {Min Wook} and Chung, {You Chul} and Jung, {Hee Chan} and Park, {Moon Seo} and Han, {Young Min} and Chung, {Yong An} and Maeng, {Lee So} and Park, {Sang In} and Jiyeon Lim and Im, {Woo Seok} and Chung, {Jin Young} and Minky Kim and Inhee Mook",

year = "2012",

month = sep,

doi = "10.1136/acupmed-2011-010126",

language = "English",

volume = "30",

pages = "222--226",

journal = "Acupuncture in Medicine",

issn = "0964-5284",

publisher = "BMJ Publishing Group",

number = "3",

}

Kim, M, Kim, MW, Chung, YC, Jung, HC, Park, MS, Han, YM, Chung, YA, Maeng, LS, Park, SI, Lim, J, Im, WS, Chung, JY, Kim, M & Mook, I 2012, 'Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction', Acupuncture in Medicine, vol. 30, no. 3, pp. 222-226. https://doi.org/10.1136/acupmed-2011-010126

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T1 - Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction

AU - Kim, Manho

AU - Kim, Min Wook

AU - Chung, You Chul

AU - Jung, Hee Chan

AU - Park, Moon Seo

AU - Han, Young Min

AU - Chung, Yong An

AU - Maeng, Lee So

AU - Park, Sang In

AU - Lim, Jiyeon

AU - Im, Woo Seok

AU - Chung, Jin Young

AU - Kim, Minky

AU - Mook, Inhee

PY - 2012/9

Y1 - 2012/9

N2 - Objective Electroacupuncture (EA) is a traditional medicine in patients with post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery. Methods Occlusion of the middle cerebral artery was performed in rats (N=12) followed by reperfusion. EA was applied at the GV20 (Baihui) acupoint. Motor and sensory functions were monitored on the Garcia scale for 2 weeks. Expressions of BDNF and receptor tyrosine kinase B (trkB) were determined by immunoblotting and immunohistochemistry. Results Improvement of Garcia scores, particularly in motor performance, were noted in the group with EA stimulation (p<0.05). With EA application, BDNF was elevated in the ischaemic hemisphere with increased numbers of BDNF(+) cells. Increased expression of trkB was also detected. Conclusion These results indicate that EA at GV20 improves motor recovery and stimulates BDNF/trkB expression in rats with cerebral ischaemia.

AB - Objective Electroacupuncture (EA) is a traditional medicine in patients with post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery. Methods Occlusion of the middle cerebral artery was performed in rats (N=12) followed by reperfusion. EA was applied at the GV20 (Baihui) acupoint. Motor and sensory functions were monitored on the Garcia scale for 2 weeks. Expressions of BDNF and receptor tyrosine kinase B (trkB) were determined by immunoblotting and immunohistochemistry. Results Improvement of Garcia scores, particularly in motor performance, were noted in the group with EA stimulation (p<0.05). With EA application, BDNF was elevated in the ischaemic hemisphere with increased numbers of BDNF(+) cells. Increased expression of trkB was also detected. Conclusion These results indicate that EA at GV20 improves motor recovery and stimulates BDNF/trkB expression in rats with cerebral ischaemia.

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Electroacupuncture enhances motor recovery performance with brain-Derived neurotrophic factor expression in rats with cerebral infarction

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