Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

Guk Young Ahn; Dong Hyun Paik; Ki Young Jeong; Seung Woon Baek; Rae Hyoung Kang; Eun Seong Lee; Sung Wook Choi

doi:10.1007/s13233-018-6089-x

Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

Guk Young Ahn
, Dong Hyun Paik
, Ki Young Jeong
, Seung Woon Baek
, Rae Hyoung Kang
, Eun Seong Lee
, Sung Wook Choi

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies. [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	573-576
Number of pages	4
Journal	Macromolecular Research
Volume	26
Issue number	7
DOIs	https://doi.org/10.1007/s13233-018-6089-x
State	Published - 1 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018, The Polymer Society of Korea and Springer Science+Business Media B.V., part of Springer Nature.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

electrospraying
folic acid
tumor therapy
ursolic acid

Access to Document

10.1007/s13233-018-6089-x

Cite this

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title = "Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy",

abstract = "We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies. [Figure not available: see fulltext.].",

keywords = "electrospraying, folic acid, tumor therapy, ursolic acid",

author = "Ahn, \{Guk Young\} and Paik, \{Dong Hyun\} and Jeong, \{Ki Young\} and Baek, \{Seung Woon\} and Kang, \{Rae Hyoung\} and Lee, \{Eun Seong\} and Choi, \{Sung Wook\}",

note = "Publisher Copyright: {\textcopyright} 2018, The Polymer Society of Korea and Springer Science+Business Media B.V., part of Springer Nature.",

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doi = "10.1007/s13233-018-6089-x",

language = "English",

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journal = "Macromolecular Research",

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T1 - Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

AU - Ahn, Guk Young

AU - Paik, Dong Hyun

AU - Jeong, Ki Young

AU - Baek, Seung Woon

AU - Kang, Rae Hyoung

AU - Lee, Eun Seong

AU - Choi, Sung Wook

PY - 2018/7/1

Y1 - 2018/7/1

N2 - We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies. [Figure not available: see fulltext.].

AB - We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro, the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies. [Figure not available: see fulltext.].

KW - electrospraying

KW - folic acid

KW - tumor therapy

KW - ursolic acid

UR - https://www.scopus.com/pages/publications/85045154459

U2 - 10.1007/s13233-018-6089-x

DO - 10.1007/s13233-018-6089-x

M3 - Article

AN - SCOPUS:85045154459

SN - 1598-5032

VL - 26

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JO - Macromolecular Research

JF - Macromolecular Research

IS - 7

ER -

Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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