Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy

Nam Muk Oh; Dong Sup Kwag; Kyung Taek Oh; Yu Seok Youn; Eun Seong Lee

doi:10.1016/j.biomaterials.2011.11.026

Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy

Nam Muk Oh, Dong Sup Kwag, Kyung Taek Oh, Yu Seok Youn, Eun Seong Lee

Department of Biomedical-Chemical Engineering

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed.

Original language	English
Pages (from-to)	1884-1893
Number of pages	10
Journal	Biomaterials
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.biomaterials.2011.11.026
State	Published - Feb 2012

Bibliographical note

Funding Information:
This work was financially supported by the Research Fund, 2011 of the Catholic University of Korea, the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (No. 2011-0003874, 2011-0004766 ), and by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy , Republic of Korea.

Keywords

Cancer chemotherapy
Photodynamic therapy
Tumor extracellular pH
Tumor-identifying polypeptide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2011.11.026

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title = "Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy",

abstract = "One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed.",

keywords = "Cancer chemotherapy, Photodynamic therapy, Tumor extracellular pH, Tumor-identifying polypeptide",

author = "Oh, {Nam Muk} and Kwag, {Dong Sup} and Oh, {Kyung Taek} and Youn, {Yu Seok} and Lee, {Eun Seong}",

note = "Funding Information: This work was financially supported by the Research Fund, 2011 of the Catholic University of Korea, the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (No. 2011-0003874, 2011-0004766 ), and by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy , Republic of Korea. ",

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AU - Oh, Nam Muk

AU - Kwag, Dong Sup

AU - Oh, Kyung Taek

AU - Youn, Yu Seok

AU - Lee, Eun Seong

N1 - Funding Information: This work was financially supported by the Research Fund, 2011 of the Catholic University of Korea, the Research Grant funded by the Gyeonggi Regional Research Center (GRRC) , by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (No. 2011-0003874, 2011-0004766 ), and by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy , Republic of Korea.

PY - 2012/2

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N2 - One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed.

AB - One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed.

KW - Cancer chemotherapy

KW - Photodynamic therapy

KW - Tumor extracellular pH

KW - Tumor-identifying polypeptide

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AN - SCOPUS:83555177185

SN - 0142-9612

VL - 33

SP - 1884

EP - 1893

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy

Abstract

Bibliographical note

Keywords

UN SDGs

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