Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study

L. Y. Hsu; D. G. Lee; S. P. Yeh; D. Bhurani; B. Q. Khanh; C. Y. Low; L. Norasetthada; T. Chan; Y. L. Kwong; A. K. Vaid; I. Alejandria; M. Mendoza; C. Y. Chen; A. Johnson; T. Y. Tan

doi:10.1016/j.cmi.2015.02.019

Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study

L. Y. Hsu
, D. G. Lee
, S. P. Yeh
, D. Bhurani
, B. Q. Khanh
, C. Y. Low
, L. Norasetthada
, T. Chan
, Y. L. Kwong
, A. K. Vaid
, I. Alejandria
, M. Mendoza
, C. Y. Chen
, A. Johnson
, T. Y. Tan

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.

Original language	English
Pages (from-to)	594.e7-594.e11
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.cmi.2015.02.019
State	Published - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 European Society of Clinical Microbiology and Infectious Diseases.

Keywords

Antifungal agents
Asia-Pacific
Epidemiology
Haematological diseases
Invasive fungal disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmi.2015.02.019

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Hsu, L. Y., Lee, D. G., Yeh, S. P., Bhurani, D., Khanh, B. Q., Low, C. Y., Norasetthada, L., Chan, T., Kwong, Y. L., Vaid, A. K., Alejandria, I., Mendoza, M., Chen, C. Y., Johnson, A., & Tan, T. Y. (2015). Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study. Clinical Microbiology and Infection, 21(6), 594.e7-594.e11. https://doi.org/10.1016/j.cmi.2015.02.019

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title = "Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study",

abstract = "We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2\% possible, 38.3\% probable and 33.5\% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9\%) or Candida spp. (26.7\%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1\%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.",

keywords = "Antifungal agents, Asia-Pacific, Epidemiology, Haematological diseases, Invasive fungal disease",

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Hsu, LY, Lee, DG, Yeh, SP, Bhurani, D, Khanh, BQ, Low, CY, Norasetthada, L, Chan, T, Kwong, YL, Vaid, AK, Alejandria, I, Mendoza, M, Chen, CY, Johnson, A & Tan, TY 2015, 'Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study', Clinical Microbiology and Infection, vol. 21, no. 6, pp. 594.e7-594.e11. https://doi.org/10.1016/j.cmi.2015.02.019

TY - JOUR

T1 - Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific

T2 - A prospective observational study

AU - Hsu, L. Y.

AU - Lee, D. G.

AU - Yeh, S. P.

AU - Bhurani, D.

AU - Khanh, B. Q.

AU - Low, C. Y.

AU - Norasetthada, L.

AU - Chan, T.

AU - Kwong, Y. L.

AU - Vaid, A. K.

AU - Alejandria, I.

AU - Mendoza, M.

AU - Chen, C. Y.

AU - Johnson, A.

AU - Tan, T. Y.

PY - 2015/6/1

Y1 - 2015/6/1

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AB - We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.

KW - Antifungal agents

KW - Asia-Pacific

KW - Epidemiology

KW - Haematological diseases

KW - Invasive fungal disease

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SN - 1198-743X

VL - 21

SP - 594.e7-594.e11

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 6

ER -

Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: A prospective observational study

Abstract

Bibliographical note

Keywords

UN SDGs

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