Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons

Mihi Yang; Je In Youn; Seung Joon Kim; Jong Y. Park

doi:10.1016/j.etap.2015.09.005

Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons

Mihi Yang, Je In Youn, Seung Joon Kim, Jong Y. Park

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

DNA methylation in promoter region can be a new chemopreventive marker against polycyclic aromatic hydrocarbons (PAHs). We performed a randomized, double blind and cross-over trial (N= 12 healthy females) to evaluate chlorella (Chlorella vulgaris)-induced epigenetic modulation on exposure to PAHs. The subjects consumed 4 tablets of placebo or chlorella supplement (total chlorophyll ≈8.3. mg/tablet) three times a day before meals for 2 weeks. When the subjects consumed chlorella, status of global hypermethylation (5-methylcytosine) was reduced, compared to placebo (p= 0.04). However, DNA methylation at the DNMT1 or NQO1 was not modified by chlorella. We observed the reduced levels of urinary 1-hydroxypyrene (1-OHP), a typical metabolite of PAHs, by chlorella intake (p<. 0.1) and a positive association between chlorella-induced changes in global hypermethylation and urinary1-OHP (p<. 0.01). Therefore, our study suggests chlorella works for PAH-detoxification through the epigenetic modulation, the interference of ADME of PAHs and the interaction of mechanisms.

Original language	English
Pages (from-to)	758-763
Number of pages	6
Journal	Environmental Toxicology and Pharmacology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.etap.2015.09.005
State	Published - 1 Nov 2015

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2005-0049410 ).

Publisher Copyright:
© 2015 Published by Elsevier B.V.

Keywords

Chlorella
Clinical trial
Epigenetic
Global methylation
Polycyclic aromatic hydrocarbons

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title = "Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons",

abstract = "DNA methylation in promoter region can be a new chemopreventive marker against polycyclic aromatic hydrocarbons (PAHs). We performed a randomized, double blind and cross-over trial (N= 12 healthy females) to evaluate chlorella (Chlorella vulgaris)-induced epigenetic modulation on exposure to PAHs. The subjects consumed 4 tablets of placebo or chlorella supplement (total chlorophyll ≈8.3. mg/tablet) three times a day before meals for 2 weeks. When the subjects consumed chlorella, status of global hypermethylation (5-methylcytosine) was reduced, compared to placebo (p= 0.04). However, DNA methylation at the DNMT1 or NQO1 was not modified by chlorella. We observed the reduced levels of urinary 1-hydroxypyrene (1-OHP), a typical metabolite of PAHs, by chlorella intake (p<. 0.1) and a positive association between chlorella-induced changes in global hypermethylation and urinary1-OHP (p<. 0.01). Therefore, our study suggests chlorella works for PAH-detoxification through the epigenetic modulation, the interference of ADME of PAHs and the interaction of mechanisms.",

keywords = "Chlorella, Clinical trial, Epigenetic, Global methylation, Polycyclic aromatic hydrocarbons",

author = "Mihi Yang and Youn, {Je In} and Kim, {Seung Joon} and Park, {Jong Y.}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2005-0049410 ). Publisher Copyright: {\textcopyright} 2015 Published by Elsevier B.V.",

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AU - Yang, Mihi

AU - Youn, Je In

AU - Kim, Seung Joon

AU - Park, Jong Y.

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2005-0049410 ). Publisher Copyright: © 2015 Published by Elsevier B.V.

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N2 - DNA methylation in promoter region can be a new chemopreventive marker against polycyclic aromatic hydrocarbons (PAHs). We performed a randomized, double blind and cross-over trial (N= 12 healthy females) to evaluate chlorella (Chlorella vulgaris)-induced epigenetic modulation on exposure to PAHs. The subjects consumed 4 tablets of placebo or chlorella supplement (total chlorophyll ≈8.3. mg/tablet) three times a day before meals for 2 weeks. When the subjects consumed chlorella, status of global hypermethylation (5-methylcytosine) was reduced, compared to placebo (p= 0.04). However, DNA methylation at the DNMT1 or NQO1 was not modified by chlorella. We observed the reduced levels of urinary 1-hydroxypyrene (1-OHP), a typical metabolite of PAHs, by chlorella intake (p<. 0.1) and a positive association between chlorella-induced changes in global hypermethylation and urinary1-OHP (p<. 0.01). Therefore, our study suggests chlorella works for PAH-detoxification through the epigenetic modulation, the interference of ADME of PAHs and the interaction of mechanisms.

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Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydrocarbons

Abstract

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