ERK1/2 activation mediated by the nutlin-3-induced mitochondrial translocation of p53

Pharmacology, Toxicology and Pharmaceutical Science

• Nutlin 3 100%
• Protein P53 100%
• Mitogen Activated Protein Kinase 3 100%
• Epidermal Growth Factor Receptor 50%
• Apoptosis 42%
• Reactive Oxygen Metabolite 28%
• Mitogen Activated Protein Kinase 28%
• Small Interfering RNA 21%
• 1,4 Diamino 1,4 Bis(2 Aminophenylthio) 2,3 Dicyanobutadiene 7%
• Phosphotransferase Inhibitor 7%
• Scavenger 7%
• Growth Disorder 7%
• Heparin Binding Epidermal Growth Factor 7%
• 4 (3 Chloroanilino) 6,7 Dimethoxyquinazoline 7%
• Ligand 7%
• Phosphotransferase 7%
• Osteosarcoma 7%
• Protein MDM2 7%
• Tyrosine Kinase Receptor 7%
• Discoidin Domain Receptor 1 7%

Neuroscience

• P53 100%
• Mitogen Activated Protein Kinase 3 100%
• Epidermal Growth Factor Receptor 50%
• Apoptosis 42%
• Phosphorylation 35%
• Reactive Oxygen Species 28%
• Mitogen-Activated Protein Kinase 21%
• Small Hairpin RNA 21%
• Receptor Phosphorylation 21%
• Kinase 14%
• Extracellular Signal-Regulated Kinases 14%
• Growth Disorder 7%
• Osteosarcoma 7%
• Negative Feedback 7%
• Heparin-Binding EGF-like Growth Factor 7%
• Protein MDM2 7%
• Discoidin Domain Receptor 1 7%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Phosphorylation 61%
• Epidermal Growth Factor Receptor 53%
• Apoptosis 46%
• Mitogen-Activated Protein Kinase 30%
• Species 30%
• Small Interfering RNA 15%
• Kinase 15%
• Extracellular Signal-Regulated Kinases 15%
• Growth 15%
• Heparin 7%
• Epidermal Growth Factor 7%
• Transcription 7%
• Small Molecule 7%
• Wild Type 7%
• Growth Factor 7%
• Protein P53 7%
• Receptor Tyrosine Kinase 7%
• Stress 7%
• Feedback System 7%
• Upregulation 7%
• Scavenger 7%