Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Jee Young Yeon; Young Jin Suh; Sang Wook Kim; Hyun Wook Baik; Chung Ja Sung; Hyun Sook Kim; Mi Kyung Sung

doi:10.1016/j.nut.2010.10.012

Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Jee Young Yeon, Young Jin Suh, Sang Wook Kim, Hyun Wook Baik, Chung Ja Sung, Hyun Sook Kim, Mi Kyung Sung

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Objective: This study was conducted to evaluate blood concentrations of inflammatory cytokines and oxidative stress-related biomarkers as risk factors of breast cancer and to determine the relation between these markers and antioxidant nutrient intake. Methods: Study subjects were 134 patients with breast cancer and 149 controls. Total antioxidant capacity and concentrations of 8-isoprostane, 8-hydroxy-2′-deoxyguanosine, interleukin (IL)-1β, IL-6, and IL-8 of blood samples were determined. A food-frequency questionnaire was used to assess nutrient intake. Results: Patients with breast cancer had significantly higher blood levels of oxidative stress markers compared with control subjects. Plasma concentrations of IL-1β and IL-6 were significantly higher in patients with breast cancer compared with those of control subjects. In the pooled analysis, total antioxidant capacity was significantly decreased with increasing quartiles of carbohydrate intake but was increased with increasing quartiles of total vitamin A intake and vitamin C intake. In addition, 8-hydroxy-2′-deoxyguanosine concentration was decreased with increasing quartiles of vitamin A and β-carotene. No significant association was found between nutrient intake and cytokine concentrations. Conclusions: These results suggest that oxidative stress and inflammation may be associated with the risk of breast cancer. Total vitamin A intake was negatively related to oxidative stresses, possibly modifying the risk of breast cancer.

Original language	English
Pages (from-to)	912-918
Number of pages	7
Journal	Nutrition
Volume	27
Issue number	9
DOIs	https://doi.org/10.1016/j.nut.2010.10.012
State	Published - Sep 2011

Bibliographical note

Funding Information:
This work was supported by the SRC Research Center for Women’s Diseases of Sookmyung Women’s University and by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2010-0001886 ).

Keywords

Antioxidant capacity
Antioxidant vitamins
Food-frequency questionnaire
Mammary tumors
Proinflammatory cytokines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nut.2010.10.012

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title = "Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk",

abstract = "Objective: This study was conducted to evaluate blood concentrations of inflammatory cytokines and oxidative stress-related biomarkers as risk factors of breast cancer and to determine the relation between these markers and antioxidant nutrient intake. Methods: Study subjects were 134 patients with breast cancer and 149 controls. Total antioxidant capacity and concentrations of 8-isoprostane, 8-hydroxy-2′-deoxyguanosine, interleukin (IL)-1β, IL-6, and IL-8 of blood samples were determined. A food-frequency questionnaire was used to assess nutrient intake. Results: Patients with breast cancer had significantly higher blood levels of oxidative stress markers compared with control subjects. Plasma concentrations of IL-1β and IL-6 were significantly higher in patients with breast cancer compared with those of control subjects. In the pooled analysis, total antioxidant capacity was significantly decreased with increasing quartiles of carbohydrate intake but was increased with increasing quartiles of total vitamin A intake and vitamin C intake. In addition, 8-hydroxy-2′-deoxyguanosine concentration was decreased with increasing quartiles of vitamin A and β-carotene. No significant association was found between nutrient intake and cytokine concentrations. Conclusions: These results suggest that oxidative stress and inflammation may be associated with the risk of breast cancer. Total vitamin A intake was negatively related to oxidative stresses, possibly modifying the risk of breast cancer.",

keywords = "Antioxidant capacity, Antioxidant vitamins, Food-frequency questionnaire, Mammary tumors, Proinflammatory cytokines",

author = "Yeon, {Jee Young} and Suh, {Young Jin} and Kim, {Sang Wook} and Baik, {Hyun Wook} and Sung, {Chung Ja} and Kim, {Hyun Sook} and Sung, {Mi Kyung}",

note = "Funding Information: This work was supported by the SRC Research Center for Women{\textquoteright}s Diseases of Sookmyung Women{\textquoteright}s University and by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2010-0001886 ). ",

year = "2011",

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doi = "10.1016/j.nut.2010.10.012",

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T1 - Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

AU - Yeon, Jee Young

AU - Suh, Young Jin

AU - Kim, Sang Wook

AU - Baik, Hyun Wook

AU - Sung, Chung Ja

AU - Kim, Hyun Sook

AU - Sung, Mi Kyung

N1 - Funding Information: This work was supported by the SRC Research Center for Women’s Diseases of Sookmyung Women’s University and by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2010-0001886 ).

PY - 2011/9

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N2 - Objective: This study was conducted to evaluate blood concentrations of inflammatory cytokines and oxidative stress-related biomarkers as risk factors of breast cancer and to determine the relation between these markers and antioxidant nutrient intake. Methods: Study subjects were 134 patients with breast cancer and 149 controls. Total antioxidant capacity and concentrations of 8-isoprostane, 8-hydroxy-2′-deoxyguanosine, interleukin (IL)-1β, IL-6, and IL-8 of blood samples were determined. A food-frequency questionnaire was used to assess nutrient intake. Results: Patients with breast cancer had significantly higher blood levels of oxidative stress markers compared with control subjects. Plasma concentrations of IL-1β and IL-6 were significantly higher in patients with breast cancer compared with those of control subjects. In the pooled analysis, total antioxidant capacity was significantly decreased with increasing quartiles of carbohydrate intake but was increased with increasing quartiles of total vitamin A intake and vitamin C intake. In addition, 8-hydroxy-2′-deoxyguanosine concentration was decreased with increasing quartiles of vitamin A and β-carotene. No significant association was found between nutrient intake and cytokine concentrations. Conclusions: These results suggest that oxidative stress and inflammation may be associated with the risk of breast cancer. Total vitamin A intake was negatively related to oxidative stresses, possibly modifying the risk of breast cancer.

AB - Objective: This study was conducted to evaluate blood concentrations of inflammatory cytokines and oxidative stress-related biomarkers as risk factors of breast cancer and to determine the relation between these markers and antioxidant nutrient intake. Methods: Study subjects were 134 patients with breast cancer and 149 controls. Total antioxidant capacity and concentrations of 8-isoprostane, 8-hydroxy-2′-deoxyguanosine, interleukin (IL)-1β, IL-6, and IL-8 of blood samples were determined. A food-frequency questionnaire was used to assess nutrient intake. Results: Patients with breast cancer had significantly higher blood levels of oxidative stress markers compared with control subjects. Plasma concentrations of IL-1β and IL-6 were significantly higher in patients with breast cancer compared with those of control subjects. In the pooled analysis, total antioxidant capacity was significantly decreased with increasing quartiles of carbohydrate intake but was increased with increasing quartiles of total vitamin A intake and vitamin C intake. In addition, 8-hydroxy-2′-deoxyguanosine concentration was decreased with increasing quartiles of vitamin A and β-carotene. No significant association was found between nutrient intake and cytokine concentrations. Conclusions: These results suggest that oxidative stress and inflammation may be associated with the risk of breast cancer. Total vitamin A intake was negatively related to oxidative stresses, possibly modifying the risk of breast cancer.

KW - Antioxidant capacity

KW - Antioxidant vitamins

KW - Food-frequency questionnaire

KW - Mammary tumors

KW - Proinflammatory cytokines

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JO - Nutrition

JF - Nutrition

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ER -

Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Abstract

Bibliographical note

Keywords

UN SDGs

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