TY - JOUR
T1 - Evaluation of Midwall Systolic Function in Left Ventricular Hypertrophy
T2 - A Comparison of 3-Dimensional Versus 2-Dimensional Echocardiographic Indices
AU - Jung, Hae Ok
AU - Sheehan, Florence H.
AU - Bolson, Edward L.
AU - Waiss, Mary Pierre
AU - Otto, Catherine M.
PY - 2006/6
Y1 - 2006/6
N2 - Objective: This study investigated the sensitivity of 3-dimensional (3D) midwall ejection fraction (EF) (3DEFmw) to the presence of left ventricular (LV) hypertrophy (LVH) in comparison with conventional echocardiographic indices for systolic function. Background: EF and fractional shortening (FS) do not reflect the prognosis of patients with LVH. Midwall mechanics better represent the true function in LVH. However, midwall FS (FSmw) interrogates a limited region of LV. We developed a method for determining 3DEFmw. Methods: This study compared 3DEFmw with 2-dimensional (endocardial EF [EFendo], endocardial FS, FSmw, and systolic tissue velocity) and 3D (3D EFendo and mitral annular motion [MAM]) echocardiographic indices in 28 patients with essential hypertension and LV mass index by M-mode greater than 125 g/m2 versus 21 healthy individuals. Results: Systolic function assessed by EFendo, endocardial FS, 3D EFendo, and systolic tissue velocity did not differ between the two groups, but MAM (11.6 vs 14.0 mm), FSmw (14.7 vs 18.2%), and 3DEFmw (36.6 vs 44.1%) were significantly decreased in LVH compared with normal. Only 3 parameters correlated significantly with both the M-mode and 3D measurements of LV mass index: FSmw (r = -0.74 [M-mode]; r = -0.48 [3D]), 3DEFmw (r = -0.63 [M-mode]; r = -0.68 [3D]), and MAM (r = -0.43 [M-mode]; r = -0.36 [3D]). Midwall indices FSmw (F = 40.4) and 3DEFmw (F = 26.5) better discriminated LVH and normal groups than MAM or endocardial indices. Conclusions: The 3DEFmw method discriminates the systolic function of LVH and normal groups, and correlates with the degree of hypertrophy. By avoiding the limitations of FSmw or MAM, 3DEFmw provides a more comprehensive metric of systolic function in patients with LVH.
AB - Objective: This study investigated the sensitivity of 3-dimensional (3D) midwall ejection fraction (EF) (3DEFmw) to the presence of left ventricular (LV) hypertrophy (LVH) in comparison with conventional echocardiographic indices for systolic function. Background: EF and fractional shortening (FS) do not reflect the prognosis of patients with LVH. Midwall mechanics better represent the true function in LVH. However, midwall FS (FSmw) interrogates a limited region of LV. We developed a method for determining 3DEFmw. Methods: This study compared 3DEFmw with 2-dimensional (endocardial EF [EFendo], endocardial FS, FSmw, and systolic tissue velocity) and 3D (3D EFendo and mitral annular motion [MAM]) echocardiographic indices in 28 patients with essential hypertension and LV mass index by M-mode greater than 125 g/m2 versus 21 healthy individuals. Results: Systolic function assessed by EFendo, endocardial FS, 3D EFendo, and systolic tissue velocity did not differ between the two groups, but MAM (11.6 vs 14.0 mm), FSmw (14.7 vs 18.2%), and 3DEFmw (36.6 vs 44.1%) were significantly decreased in LVH compared with normal. Only 3 parameters correlated significantly with both the M-mode and 3D measurements of LV mass index: FSmw (r = -0.74 [M-mode]; r = -0.48 [3D]), 3DEFmw (r = -0.63 [M-mode]; r = -0.68 [3D]), and MAM (r = -0.43 [M-mode]; r = -0.36 [3D]). Midwall indices FSmw (F = 40.4) and 3DEFmw (F = 26.5) better discriminated LVH and normal groups than MAM or endocardial indices. Conclusions: The 3DEFmw method discriminates the systolic function of LVH and normal groups, and correlates with the degree of hypertrophy. By avoiding the limitations of FSmw or MAM, 3DEFmw provides a more comprehensive metric of systolic function in patients with LVH.
UR - http://www.scopus.com/inward/record.url?scp=33744537307&partnerID=8YFLogxK
U2 - 10.1016/j.echo.2006.01.007
DO - 10.1016/j.echo.2006.01.007
M3 - Article
C2 - 16762760
AN - SCOPUS:33744537307
SN - 0894-7317
VL - 19
SP - 802
EP - 810
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 6
ER -