Abstract
We have investigated the expression and cellular localization of brain/kidney (B/K) protein in the rat retina following transient ischemia. In the normal retina, strong B/K immunoreactivity was localized to some ganglion cells. In addition, a few radial Muller cell processes showed B/K immunoreactivity. Following ischemia and reperfusion, most B/K-labeled ganglion cells were lost, whereas between 1 day and 2 weeks post-lesion B/K immunoreactivity appeared in many more Muller cell processes with increasing intensity. Quantitative evaluation by immunoblotting confirmed that B/K expression then decreased progressively, to 35% of control values at four weeks post-lesion. Our findings suggest that Muller cells are involved in the pathophysiology of retinal ischemia through the expression of B/K following transient ischemia. Copyright (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 53-56 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 293 |
| Issue number | 1 |
| DOIs | |
| State | Published - 20 Oct 2000 |
Bibliographical note
Funding Information:This work was supported by grants from the Ministry of Health & Welfare (Health 21 R&D Project, HMP-00-B-21300-0209), and by Brain Korea 21, Republic of Korea. We are grateful to H.-D. Rho and B.-W. Hong for technical assistance.
Keywords
- Brain Kidney protein
- Ischemia
- Muller cells
- Rat
- Retina
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