Abstract
Examining the distribution of osteopontin (OPN) in the rat brain using in situ hybridization, it was found that OPN mRNA was restricted to likely neurons in the olfactory bulb and the brain stem; it was not detected in the telencephalon and the diencephalon. In addition, Northern blot analysis showed a confined expression only in the brain stem with higher level in the pons and the medulla than in the midbrain. In the brain stem, it was found in functionally diverse areas including motor-related areas, sensory system and reticular formation. This specific but widespread distribution suggests that OPN may play an important role in the adult rat brain. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 273 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Oct 1999 |
Bibliographical note
Funding Information:We are grateful to Dr. Suk Kyeong Lee at the Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea for improving the manuscript, and Mrs. Hee-Duck Rho and Byoung-Ouk Hong for their excellent technical assistance. The authors wish to acknowledge the financial support of the Korea Research Foundation made in the program year of 1997.
Keywords
- Brain stem
- In situ hybridization
- Northern blot analysis
- Olfactory bulb
- Osteopontin
- Rat
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