Expression of trefoil peptides in the subtypes of intestinal metaplasia

Byung Wook Kim; Kyoung Mee Kim; Bo In Lee; Lee So Maeng; Hwang Choi; Se Hyun Cho; Hiun Suk Chae; Jae Kwang Kim; Kyu Yong Choi; In Sik Chung

doi:10.1016/j.peptides.2003.12.021

Expression of trefoil peptides in the subtypes of intestinal metaplasia

Byung Wook Kim
, Kyoung Mee Kim
, Bo In Lee
, Lee So Maeng
, Hwang Choi
, Se Hyun Cho
, Hiun Suk Chae
, Jae Kwang Kim
, Kyu Yong Choi
, In Sik Chung

Department of Internal Medicine

The Catholic University of Korea

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.

Original language	English
Pages (from-to)	779-783
Number of pages	5
Journal	Peptides
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2003.12.021
State	Published - May 2004

Bibliographical note

Funding Information:
We thank Dr. N. Wright and G. Elia of Cancer Research UK, London, UK for providing the TFF1 and TFF2 mouse monoclonal antibodies. We also thank Dr. A. Giraud of the University of Melbourne, Melbourne, Australia for providing the TFF3 rat polyclonal antibody. This study was partially supported by the Research Institute of Clinical Medicine, Our Lady of Mercy Hospital, The Catholic University of Korea.

Keywords

Immunohistochemistry
Metaplasia
Stomach
Trefoil peptide

Access to Document

10.1016/j.peptides.2003.12.021

Cite this

@article{66c1b32ce3974818b8dc3c49b6e308e2,

title = "Expression of trefoil peptides in the subtypes of intestinal metaplasia",

abstract = "We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.",

keywords = "Immunohistochemistry, Metaplasia, Stomach, Trefoil peptide",

author = "Kim, \{Byung Wook\} and Kim, \{Kyoung Mee\} and Lee, \{Bo In\} and Maeng, \{Lee So\} and Hwang Choi and Cho, \{Se Hyun\} and Chae, \{Hiun Suk\} and Kim, \{Jae Kwang\} and Choi, \{Kyu Yong\} and Chung, \{In Sik\}",

note = "Funding Information: We thank Dr. N. Wright and G. Elia of Cancer Research UK, London, UK for providing the TFF1 and TFF2 mouse monoclonal antibodies. We also thank Dr. A. Giraud of the University of Melbourne, Melbourne, Australia for providing the TFF3 rat polyclonal antibody. This study was partially supported by the Research Institute of Clinical Medicine, Our Lady of Mercy Hospital, The Catholic University of Korea. ",

year = "2004",

month = may,

doi = "10.1016/j.peptides.2003.12.021",

language = "English",

volume = "25",

pages = "779--783",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Expression of trefoil peptides in the subtypes of intestinal metaplasia

AU - Kim, Byung Wook

AU - Kim, Kyoung Mee

AU - Lee, Bo In

AU - Maeng, Lee So

AU - Choi, Hwang

AU - Cho, Se Hyun

AU - Chae, Hiun Suk

AU - Kim, Jae Kwang

AU - Choi, Kyu Yong

AU - Chung, In Sik

N1 - Funding Information: We thank Dr. N. Wright and G. Elia of Cancer Research UK, London, UK for providing the TFF1 and TFF2 mouse monoclonal antibodies. We also thank Dr. A. Giraud of the University of Melbourne, Melbourne, Australia for providing the TFF3 rat polyclonal antibody. This study was partially supported by the Research Institute of Clinical Medicine, Our Lady of Mercy Hospital, The Catholic University of Korea.

PY - 2004/5

Y1 - 2004/5

N2 - We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.

AB - We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.

KW - Immunohistochemistry

KW - Metaplasia

KW - Stomach

KW - Trefoil peptide

UR - https://www.scopus.com/pages/publications/2642535868

U2 - 10.1016/j.peptides.2003.12.021

DO - 10.1016/j.peptides.2003.12.021

M3 - Article

C2 - 15177872

AN - SCOPUS:2642535868

SN - 0196-9781

VL - 25

SP - 779

EP - 783

JO - Peptides

JF - Peptides

IS - 5

ER -

Expression of trefoil peptides in the subtypes of intestinal metaplasia

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this