Abstract
Nanodiamond (ND)-based nanoparticles with hyaluronic acid (HA) and chlorin e6 (Ce6) were fabricated for potential photodynamic and photothermal tumor therapy. The ND nanoparticles conjugated with HA and Ce6 (Ce6-ND@HA) had a suitable size range about 130 nm and high zeta-potential about −35 mV. The conjugation was confirmed by UV-vis spectroscopy and the conjugation efficiency of Ce6 in these ND nanoparticles was quantified by fluorescence emission spectrum. HeLa and NIH/3T3 cell lines were used as model cells in order to evaluate the performance of ND, ND nanoparticles with HA (ND@HA), and Ce6-ND@HA. The ND@HA and Ce6-ND@HA nanoparticles had a selective uptake for HeLa cells due to the presence of HA. In addition, Ce6-ND@HA nanoparticles had a high cell ablation effect for HeLa cells due to the temperature increase caused by ND and singlet oxygen generation caused by Ce6. These results suggest that Ce6-ND@HA particles might have potential for targeted anti-tumor treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 2990-2998 |
| Number of pages | 9 |
| Journal | Polymers for Advanced Technologies |
| Volume | 31 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Dec 2020 |
Bibliographical note
Publisher Copyright:© 2020 John Wiley & Sons Ltd
Keywords
- Chlorin e6
- hyaluronic acid
- nanodiamond
- photodynamic therapy
- photothermal therapy
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