TY - JOUR
T1 - Factors associated with right ventricular dilatation and dysfunction in patients with chronic pulmonary regurgitation after repair of tetralogy of Fallot
T2 - Analysis of magnetic resonance imaging data from 218 patients
AU - Lee, Cheul
AU - Lee, Chang Ha
AU - Kwak, Jae Gun
AU - Kim, Seong Ho
AU - Shim, Woo Sup
AU - Lee, Sang Yun
AU - Jang, So Ick
AU - Park, Su Jin
AU - Kim, Yang Min
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective The aim of the present study was to identify the factors associated with right ventricular (RV) dilatation and dysfunction in patients with chronic pulmonary regurgitation (PR) after repair of tetralogy of Fallot.Results On univariable analysis, male sex, ventricular septal defect (VSD) closure through the right ventricle, larger pulmonary artery index, and greater PR fraction were associated with greater RV volume indexes. Multivariable analyses identified male sex (β = 17.55, P <.001 for RV EDVI; β = 14.08, P =.001 for RV ESVI), VSD closure through RV (β = 8.49, P =.048 for RV ESVI), longer interval since repair (β = 1.29, P =.014 for RV EDVI), and greater PR fraction (β = 1.92, P <.001 for RV EDVI; β = 1.38, P <.001 for RV ESVI) as independent predictors for greater RV volume indexes. On univariable analysis, male sex, VSD closure through the right ventricle, and greater PR fraction were associated with a lower RV ejection fraction. Multivariable analysis identified male sex (β = -3.10, P =.018), VSD closure through the right ventricle (β = -3.05, P =.020), and greater PR fraction (β = -0.27, P <.001) as independent predictors for a lower RV ejection fraction.Conclusions Male sex, VSD closure through the right ventricle, longer interval since repair, and greater PR fraction were independent predictors of RV dilatation after tetralogy of Fallot repair. Male sex, VSD closure through the right ventricle, and greater PR fraction were also independent predictors of RV dysfunction.
AB - Objective The aim of the present study was to identify the factors associated with right ventricular (RV) dilatation and dysfunction in patients with chronic pulmonary regurgitation (PR) after repair of tetralogy of Fallot.Results On univariable analysis, male sex, ventricular septal defect (VSD) closure through the right ventricle, larger pulmonary artery index, and greater PR fraction were associated with greater RV volume indexes. Multivariable analyses identified male sex (β = 17.55, P <.001 for RV EDVI; β = 14.08, P =.001 for RV ESVI), VSD closure through RV (β = 8.49, P =.048 for RV ESVI), longer interval since repair (β = 1.29, P =.014 for RV EDVI), and greater PR fraction (β = 1.92, P <.001 for RV EDVI; β = 1.38, P <.001 for RV ESVI) as independent predictors for greater RV volume indexes. On univariable analysis, male sex, VSD closure through the right ventricle, and greater PR fraction were associated with a lower RV ejection fraction. Multivariable analysis identified male sex (β = -3.10, P =.018), VSD closure through the right ventricle (β = -3.05, P =.020), and greater PR fraction (β = -0.27, P <.001) as independent predictors for a lower RV ejection fraction.Conclusions Male sex, VSD closure through the right ventricle, longer interval since repair, and greater PR fraction were independent predictors of RV dilatation after tetralogy of Fallot repair. Male sex, VSD closure through the right ventricle, and greater PR fraction were also independent predictors of RV dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=84919960540&partnerID=8YFLogxK
U2 - 10.1016/j.jtcvs.2014.07.051
DO - 10.1016/j.jtcvs.2014.07.051
M3 - Article
C2 - 25173118
AN - SCOPUS:84919960540
SN - 0022-5223
VL - 148
SP - 2589
EP - 2596
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 6
ER -