Fast integrated intravascular photoacoustic/ultrasound catheter

Changhoon Choi; Seunghee Cho; Taehoon Kim; Sungjo Park; Hyoeun Park; Jinmoo Kim; Seunghoon Lee; Yeonsu Kang; Kiyuk Jang; Chulhong Kim

doi:10.1117/12.2210790

Fast integrated intravascular photoacoustic/ultrasound catheter

Changhoon Choi, Seunghee Cho, Taehoon Kim, Sungjo Park, Hyoeun Park, Jinmoo Kim, Seunghoon Lee, Yeonsu Kang, Kiyuk Jang, Chulhong Kim

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

In cardiology, a vulnerable plaque is considered to be a key subject because it is strongly related to atherosclerosis and acute myocardial infarction. Because conventional intravascular imaging devices exhibit several limitations with regard to vulnerable plaque detection, the need for an effective lipid imaging modality has been continuously suggested. Photoacoustic (PA) imaging is a medical imaging technique with a high level of ultrasound (US) resolution and strong optical contrast. In this study, we successfully developed an integrated intravascular photoacoustic/ultrasound (IV-PAUS) imaging system with a catheter diameter of 1.2 mm for lipid-rich atherosclerosis imaging. An Nd:YAG pulsed laser with an excitation wavelength of 1064 nm was utilized. IV-PAUS offers 5-mm depth penetration and axial and lateral PA imaging resolutions of 94 μm and 203 μm, respectively, as determined by imaging a 6-μm carbon fiber. We initially obtained 3-dimensional (3D) co-registered PA/US images of metal stents. Subsequently, we successfully obtained 3D coregistered PA/US ex vivo images using an iliac artery from a rabbit atherosclerosis model. Accordingly, lipid-rich plaques were sufficiently differentiated from normal tissue in the ex vivo experiment. We validated these findings histologically to confirm the lipid content.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2016
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781628419429
DOIs	https://doi.org/10.1117/12.2210790
State	Published - 2016
Event	Photons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States Duration: 14 Feb 2016 → 17 Feb 2016

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9708
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2016
Country/Territory	United States
City	San Francisco
Period	14/02/16 → 17/02/16

Bibliographical note

Funding Information:
This work was supported by an NRF Engineering Research Center grant (NRF-2011-0030075) from the Ministry of Science, ICT, and Future Planning (MSIP), Korea under the 'ICT Consilience Creative Program' (IITP-2015-R0346-15-1007) supervised by the IITP (Institute for Information and Communications Technology Promotion) and a grant (HI15C1817) from the Korea Health Technology RandD Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea.

Publisher Copyright:
© 2016 SPIE.

Keywords

atherosclerosis
cardiac disease
intravascular catheter
intravascular imaging
Photoacoustic endoscopy
vulnerable plaque

Access to Document

10.1117/12.2210790

Cite this

Choi, C., Cho, S., Kim, T., Park, S., Park, H., Kim, J., Lee, S., Kang, Y., Jang, K., & Kim, C. (2016). Fast integrated intravascular photoacoustic/ultrasound catheter. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2016 Article 970854 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9708). SPIE. https://doi.org/10.1117/12.2210790

@inproceedings{55d1896f694c47e887a0fb2c5f625091,

title = "Fast integrated intravascular photoacoustic/ultrasound catheter",

abstract = "In cardiology, a vulnerable plaque is considered to be a key subject because it is strongly related to atherosclerosis and acute myocardial infarction. Because conventional intravascular imaging devices exhibit several limitations with regard to vulnerable plaque detection, the need for an effective lipid imaging modality has been continuously suggested. Photoacoustic (PA) imaging is a medical imaging technique with a high level of ultrasound (US) resolution and strong optical contrast. In this study, we successfully developed an integrated intravascular photoacoustic/ultrasound (IV-PAUS) imaging system with a catheter diameter of 1.2 mm for lipid-rich atherosclerosis imaging. An Nd:YAG pulsed laser with an excitation wavelength of 1064 nm was utilized. IV-PAUS offers 5-mm depth penetration and axial and lateral PA imaging resolutions of 94 μm and 203 μm, respectively, as determined by imaging a 6-μm carbon fiber. We initially obtained 3-dimensional (3D) co-registered PA/US images of metal stents. Subsequently, we successfully obtained 3D coregistered PA/US ex vivo images using an iliac artery from a rabbit atherosclerosis model. Accordingly, lipid-rich plaques were sufficiently differentiated from normal tissue in the ex vivo experiment. We validated these findings histologically to confirm the lipid content.",

keywords = "atherosclerosis, cardiac disease, intravascular catheter, intravascular imaging, Photoacoustic endoscopy, vulnerable plaque",

author = "Changhoon Choi and Seunghee Cho and Taehoon Kim and Sungjo Park and Hyoeun Park and Jinmoo Kim and Seunghoon Lee and Yeonsu Kang and Kiyuk Jang and Chulhong Kim",

note = "Funding Information: This work was supported by an NRF Engineering Research Center grant (NRF-2011-0030075) from the Ministry of Science, ICT, and Future Planning (MSIP), Korea under the 'ICT Consilience Creative Program' (IITP-2015-R0346-15-1007) supervised by the IITP (Institute for Information and Communications Technology Promotion) and a grant (HI15C1817) from the Korea Health Technology RandD Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea. Publisher Copyright: {\textcopyright} 2016 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2016 ; Conference date: 14-02-2016 Through 17-02-2016",

year = "2016",

doi = "10.1117/12.2210790",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",

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Choi, C, Cho, S, Kim, T, Park, S, Park, H, Kim, J, Lee, S, Kang, Y, Jang, K & Kim, C 2016, Fast integrated intravascular photoacoustic/ultrasound catheter. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2016., 970854, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9708, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2016, San Francisco, United States, 14/02/16. https://doi.org/10.1117/12.2210790

Fast integrated intravascular photoacoustic/ultrasound catheter. / Choi, Changhoon; Cho, Seunghee; Kim, Taehoon et al.
Photons Plus Ultrasound: Imaging and Sensing 2016. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2016. 970854 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9708).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Fast integrated intravascular photoacoustic/ultrasound catheter

AU - Choi, Changhoon

AU - Cho, Seunghee

AU - Kim, Taehoon

AU - Park, Sungjo

AU - Park, Hyoeun

AU - Kim, Jinmoo

AU - Lee, Seunghoon

AU - Kang, Yeonsu

AU - Jang, Kiyuk

AU - Kim, Chulhong

N1 - Funding Information: This work was supported by an NRF Engineering Research Center grant (NRF-2011-0030075) from the Ministry of Science, ICT, and Future Planning (MSIP), Korea under the 'ICT Consilience Creative Program' (IITP-2015-R0346-15-1007) supervised by the IITP (Institute for Information and Communications Technology Promotion) and a grant (HI15C1817) from the Korea Health Technology RandD Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea. Publisher Copyright: © 2016 SPIE.

PY - 2016

Y1 - 2016

N2 - In cardiology, a vulnerable plaque is considered to be a key subject because it is strongly related to atherosclerosis and acute myocardial infarction. Because conventional intravascular imaging devices exhibit several limitations with regard to vulnerable plaque detection, the need for an effective lipid imaging modality has been continuously suggested. Photoacoustic (PA) imaging is a medical imaging technique with a high level of ultrasound (US) resolution and strong optical contrast. In this study, we successfully developed an integrated intravascular photoacoustic/ultrasound (IV-PAUS) imaging system with a catheter diameter of 1.2 mm for lipid-rich atherosclerosis imaging. An Nd:YAG pulsed laser with an excitation wavelength of 1064 nm was utilized. IV-PAUS offers 5-mm depth penetration and axial and lateral PA imaging resolutions of 94 μm and 203 μm, respectively, as determined by imaging a 6-μm carbon fiber. We initially obtained 3-dimensional (3D) co-registered PA/US images of metal stents. Subsequently, we successfully obtained 3D coregistered PA/US ex vivo images using an iliac artery from a rabbit atherosclerosis model. Accordingly, lipid-rich plaques were sufficiently differentiated from normal tissue in the ex vivo experiment. We validated these findings histologically to confirm the lipid content.

AB - In cardiology, a vulnerable plaque is considered to be a key subject because it is strongly related to atherosclerosis and acute myocardial infarction. Because conventional intravascular imaging devices exhibit several limitations with regard to vulnerable plaque detection, the need for an effective lipid imaging modality has been continuously suggested. Photoacoustic (PA) imaging is a medical imaging technique with a high level of ultrasound (US) resolution and strong optical contrast. In this study, we successfully developed an integrated intravascular photoacoustic/ultrasound (IV-PAUS) imaging system with a catheter diameter of 1.2 mm for lipid-rich atherosclerosis imaging. An Nd:YAG pulsed laser with an excitation wavelength of 1064 nm was utilized. IV-PAUS offers 5-mm depth penetration and axial and lateral PA imaging resolutions of 94 μm and 203 μm, respectively, as determined by imaging a 6-μm carbon fiber. We initially obtained 3-dimensional (3D) co-registered PA/US images of metal stents. Subsequently, we successfully obtained 3D coregistered PA/US ex vivo images using an iliac artery from a rabbit atherosclerosis model. Accordingly, lipid-rich plaques were sufficiently differentiated from normal tissue in the ex vivo experiment. We validated these findings histologically to confirm the lipid content.

KW - atherosclerosis

KW - cardiac disease

KW - intravascular catheter

KW - intravascular imaging

KW - Photoacoustic endoscopy

KW - vulnerable plaque

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DO - 10.1117/12.2210790

M3 - Conference contribution

AN - SCOPUS:84975044328

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

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PB - SPIE

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Y2 - 14 February 2016 through 17 February 2016

ER -

Fast integrated intravascular photoacoustic/ultrasound catheter

Abstract

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Bibliographical note

Keywords

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