Abstract
Acute-on-chronic liver failure (ACLF) occurs in the presence of a chronic liver disease or cirrhosis, and often results from exacerbation of chronic hepatitis B (CHB). The efficacy of corticosteroid treatment in ACLF patients with underlying CHB remains unclear. We report the case of a 50-year-old woman who experienced ACLF due to CHB exacerbation and was treated with a combination of corticosteroids and nucleot(s)ide analogue (NUC). The patient showed rapid decompensation due to CHB exacerbation. Three months of antiviral therapy produced no improvement in liver function. Combination therapy with corticosteroids and NUC was started, which did result in improvement of liver function. This case shows that the combined therapy of corticosteroids and NUC can be effective in treating ACLF due to CHB exacerbation.
| Original language | English |
|---|---|
| Pages (from-to) | 430-435 |
| Number of pages | 6 |
| Journal | Clinical and Molecular Hepatology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Dec 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Acute-on-chronic liver failure
- Chronic hepatitis B
- Corticosteroid
- Exacerbation
- Reactivation
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