Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

Yong Sam Kim; Jee Ae Jung; Hyun Jung Kim; Yeong Hee Ahn; Jong Shin Yoo; Sejeong Oh; Changhee Cho; Hyang Sook Yoo; Jeong Heon Ko

doi:10.1016/j.bbrc.2010.11.071

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

Yong Sam Kim
, Jee Ae Jung
, Hyun Jung Kim
, Yeong Hee Ahn
, Jong Shin Yoo
, Sejeong Oh
, Changhee Cho
, Hyang Sook Yoo
, Jeong Heon Ko

Department of Surgery

Korea Research Institute of Bioscience and Biotechnology
Korea Basic Science Institute
University of Science and Technology UST

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.

Original language	English
Pages (from-to)	96-102
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	404
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2010.11.071
State	Published - 7 Jan 2011

Bibliographical note

Funding Information:
This work was supported by the ‘ Leading Foreign Research Institute Recruitment Program ’, the ‘Complex Carbohydrate Research Program’ and ‘ Convergence Research Center Program ( 2010K001115 )’ of the Ministry of Education, Science and Technology. Especially, we express deep appreciation to Daejeon metropolitan city for its support.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Galectin-3
Galectin-3 binding protein
PTPκ shedding
Proprotein convertase 5

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10.1016/j.bbrc.2010.11.071

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Kim, Y. S., Jung, J. A., Kim, H. J., Ahn, Y. H., Yoo, J. S., Oh, S., Cho, C., Yoo, H. S., & Ko, J. H. (2011). Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5. Biochemical and Biophysical Research Communications, 404(1), 96-102. https://doi.org/10.1016/j.bbrc.2010.11.071

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title = "Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5",

abstract = "It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.",

keywords = "Galectin-3, Galectin-3 binding protein, PTPκ shedding, Proprotein convertase 5",

author = "Kim, \{Yong Sam\} and Jung, \{Jee Ae\} and Kim, \{Hyun Jung\} and Ahn, \{Yeong Hee\} and Yoo, \{Jong Shin\} and Sejeong Oh and Changhee Cho and Yoo, \{Hyang Sook\} and Ko, \{Jeong Heon\}",

note = "Funding Information: This work was supported by the {\textquoteleft} Leading Foreign Research Institute Recruitment Program {\textquoteright}, the {\textquoteleft}Complex Carbohydrate Research Program{\textquoteright} and {\textquoteleft} Convergence Research Center Program ( 2010K001115 ){\textquoteright} of the Ministry of Education, Science and Technology. Especially, we express deep appreciation to Daejeon metropolitan city for its support.",

year = "2011",

month = jan,

day = "7",

doi = "10.1016/j.bbrc.2010.11.071",

language = "English",

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Kim, YS, Jung, JA, Kim, HJ, Ahn, YH, Yoo, JS, Oh, S, Cho, C, Yoo, HS & Ko, JH 2011, 'Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5', Biochemical and Biophysical Research Communications, vol. 404, no. 1, pp. 96-102. https://doi.org/10.1016/j.bbrc.2010.11.071

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5. / Kim, Yong Sam; Jung, Jee Ae; Kim, Hyun Jung et al.
In: Biochemical and Biophysical Research Communications, Vol. 404, No. 1, 07.01.2011, p. 96-102.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

AU - Kim, Yong Sam

AU - Jung, Jee Ae

AU - Kim, Hyun Jung

AU - Ahn, Yeong Hee

AU - Yoo, Jong Shin

AU - Oh, Sejeong

AU - Cho, Changhee

AU - Yoo, Hyang Sook

AU - Ko, Jeong Heon

N1 - Funding Information: This work was supported by the ‘ Leading Foreign Research Institute Recruitment Program ’, the ‘Complex Carbohydrate Research Program’ and ‘ Convergence Research Center Program ( 2010K001115 )’ of the Ministry of Education, Science and Technology. Especially, we express deep appreciation to Daejeon metropolitan city for its support.

PY - 2011/1/7

Y1 - 2011/1/7

N2 - It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.

AB - It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.

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KW - Galectin-3 binding protein

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KW - Proprotein convertase 5

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AN - SCOPUS:78650895502

SN - 0006-291X

VL - 404

SP - 96

EP - 102

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

Abstract

Bibliographical note

UN SDGs

Keywords

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