TY - JOUR
T1 - Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention
T2 - Insights from the KAMIR-NIH Registry
AU - KAMIR-NIH registry investigators
AU - Lee, Myunhee
AU - Kim, Dae Won
AU - Park, Mahn Won
AU - Lee, Kyusup
AU - Chang, Kiyuk
AU - Chung, Wook Sung
AU - Ahn, Tae Hoon
AU - Jeong, Myung Ho
AU - Rha, Seung Woon
AU - Kim, Hyo Soo
AU - Gwon, Hyeon Cheol
AU - Seong, In Whan
AU - Hwang, Kyung Kuk
AU - Chae, Shung Chull
AU - Kim, Kwon Bae
AU - Kim, Young Jo
AU - Cha, Kwang Soo
AU - Oh, Seok Kyu
AU - Chae, Jei Keon
AU - Jung, Ji Hoon
N1 - Funding Information:
This research was funded by Research of Korea Centers for Disease Control and Prevention and the Korea Health Technology R & D Project (2016-ER6304-01), Ministry of Health & Welfare (HI13C1527), South Korea. The authors declared no conflicts of interests.
Publisher Copyright:
© 2020 JGC All rights reserved; www.jgc301.com
PY - 2020
Y1 - 2020
N2 - Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into male (n = 8021, 75.9%) and female (n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using propensity score (PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction (NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population (30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585; 1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328; TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.
AB - Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into male (n = 8021, 75.9%) and female (n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using propensity score (PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction (NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population (30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585; 1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328; TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.
KW - Acute myocardial infarction
KW - Asian population
KW - Gender difference
KW - Percutaneous coronary intervention
UR - http://www.scopus.com/inward/record.url?scp=85104847529&partnerID=8YFLogxK
U2 - 10.11909/j.issn.1671-5411.2020.11.006
DO - 10.11909/j.issn.1671-5411.2020.11.006
M3 - Article
AN - SCOPUS:85104847529
SN - 1671-5411
VL - 17
SP - 680
EP - 693
JO - Journal of Geriatric Cardiology
JF - Journal of Geriatric Cardiology
IS - 11
ER -