Gender-specific associations between low skeletal muscle mass and albuminuria in the middle-aged and elderly population

Hye Eun Yoon, Yunju Nam, Eunjin Kang, Hyeon Seok Hwang, Seok Joon Shin, Yeon Sik Hong, Kwi Young Kang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective This study assessed gender-specific associations between low muscle mass (LMM) and albuminuria. Methods Data from the Korea National Health and Nutrition Examination Survey 2011 were employed. The study consisted of 1,087 subjects (≥50 years old). Skeletal muscle index (SMI) was defined as the weight-adjusted appendicular skeletal muscle mass. Mild LMM and severe LMM were defined as SMI that were 1-2 and >2 standard deviations below the sex-specific mean appendicular skeletal muscle mass of young adults, respectively. Increased albuminuria was defined as albumin-to-creatinine ratio ≥30mg/g Results Men with mild and severe LMM were significantly more likely to have increased albuminuria (15.2% and 45.45%, respectively) than men with normal SMI (9.86%, P<0.0001), but not women. Severe LMM associated independently with increased albuminuria in men (OR=7.661, 95% CI=2.72-21.579) but not women. Severe LMM was an independent predictor of increased albuminuria in hypertensive males (OR=11.449, 95% CI=3.037-43.156), non-diabetic males (OR=8.782, 95% CI=3.046-25.322), and males without metabolic syndrome (MetS) (OR=8.183, 95% CI=1.539-43.156). This was not observed in males without hypertension, males with diabetes or MetS, and all female subgroups. Conclusion Severe LMM associated with increased albuminuria in men, especially those with hypertension and without diabetes or MetS.

Original languageEnglish
Pages (from-to)1054-1064
Number of pages11
JournalInternational Journal of Medical Sciences
Volume14
Issue number11
DOIs
StatePublished - 3 Sep 2017

Bibliographical note

Publisher Copyright:
© Ivyspring International Publisher.

Keywords

  • Albuminuria
  • Hypertension
  • Low skeletal muscle mass
  • Male

Fingerprint

Dive into the research topics of 'Gender-specific associations between low skeletal muscle mass and albuminuria in the middle-aged and elderly population'. Together they form a unique fingerprint.

Cite this