Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

Daye Baek; Kun Gu Lee; Hee Young Sohn; Jung Hyun Park; Hye Kyung Lee; Govigerel Bayarsaikhan; Sang Won Yoo; Bonghee Lee; Joong Seok Kim; Young Ho Koh; Munjin Kwon

doi:10.1016/j.scr.2024.103358

Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

Daye Baek, Kun Gu Lee, Hee Young Sohn, Jung Hyun Park, Hye Kyung Lee, Govigerel Bayarsaikhan, Sang Won Yoo, Bonghee Lee, Joong Seok Kim, Young Ho Koh, Munjin Kwon

Department of Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.

Original language	English
Article number	103358
Journal	Stem Cell Research
Volume	76
DOIs	https://doi.org/10.1016/j.scr.2024.103358
State	Published - Apr 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Access to Document

10.1016/j.scr.2024.103358

Cite this

Baek, D., Lee, K. G., Sohn, H. Y., Park, J. H., Lee, H. K., Bayarsaikhan, G., Yoo, S. W., Lee, B., Kim, J. S., Koh, Y. H., & Kwon, M. (2024). Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease. Stem Cell Research, 76, Article 103358. https://doi.org/10.1016/j.scr.2024.103358

@article{c7849123ad5d416eb856e901266ff0c5,

title = "Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease",

abstract = "Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.",

author = "Daye Baek and Lee, {Kun Gu} and Sohn, {Hee Young} and Park, {Jung Hyun} and Lee, {Hye Kyung} and Govigerel Bayarsaikhan and Yoo, {Sang Won} and Bonghee Lee and Kim, {Joong Seok} and Koh, {Young Ho} and Munjin Kwon",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = apr,

doi = "10.1016/j.scr.2024.103358",

language = "English",

volume = "76",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

AU - Baek, Daye

AU - Lee, Kun Gu

AU - Sohn, Hee Young

AU - Park, Jung Hyun

AU - Lee, Hye Kyung

AU - Bayarsaikhan, Govigerel

AU - Yoo, Sang Won

AU - Lee, Bonghee

AU - Kim, Joong Seok

AU - Koh, Young Ho

AU - Kwon, Munjin

PY - 2024/4

Y1 - 2024/4

N2 - Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.

AB - Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.

UR - http://www.scopus.com/inward/record.url?scp=85186685047&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2024.103358

DO - 10.1016/j.scr.2024.103358

M3 - Article

C2 - 38447455

AN - SCOPUS:85186685047

SN - 1873-5061

VL - 76

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 103358

ER -

Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this