Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells

Gil Saeng Jeong; Bin Li; Dong Sung Lee; Ji Wung Kwon; Hye Suk Lee; Tae Oh Kwon; Youn Chul Kim

Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells

Gil Saeng Jeong
, Bin Li
, Dong Sung Lee
, Ji Wung Kwon
, Hye Suk Lee
, Tae Oh Kwon
, Youn Chul Kim

Wonkwang University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Five lignans, sauchinone (1), di-O-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saurunis chinensis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 2, and 5 showed significant protective effects with the EC₅₀ values of 74.2±0.9, 111.3±0.8, 64.3±0.8 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC₅₀ value of 86.2±0.5 μM.

Original language	English
Pages (from-to)	176-180
Number of pages	5
Journal	Korean Journal of Pharmacognosy
Volume	38
Issue number	2
State	Published - Jun 2007

Keywords

Hep G2 cells
Hepatoprotective
Saurunis chinensis
Saururaceae
Tacrine

Cite this

@article{6477e7d592254833896ba7edf643643d,

title = "Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells",

abstract = "Five lignans, sauchinone (1), di-O-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saurunis chinensis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 2, and 5 showed significant protective effects with the EC50 values of 74.2±0.9, 111.3±0.8, 64.3±0.8 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC50 value of 86.2±0.5 μM.",

keywords = "Hep G2 cells, Hepatoprotective, Saurunis chinensis, Saururaceae, Tacrine",

author = "Jeong, \{Gil Saeng\} and Bin Li and Lee, \{Dong Sung\} and Kwon, \{Ji Wung\} and Lee, \{Hye Suk\} and Kwon, \{Tae Oh\} and Kim, \{Youn Chul\}",

year = "2007",

month = jun,

language = "English",

volume = "38",

pages = "176--180",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

number = "2",

}

TY - JOUR

T1 - Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells

AU - Jeong, Gil Saeng

AU - Li, Bin

AU - Lee, Dong Sung

AU - Kwon, Ji Wung

AU - Lee, Hye Suk

AU - Kwon, Tae Oh

AU - Kim, Youn Chul

PY - 2007/6

Y1 - 2007/6

N2 - Five lignans, sauchinone (1), di-O-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saurunis chinensis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 2, and 5 showed significant protective effects with the EC50 values of 74.2±0.9, 111.3±0.8, 64.3±0.8 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC50 value of 86.2±0.5 μM.

AB - Five lignans, sauchinone (1), di-O-methyltetrahydrofuriguaiacin B (2), manassantin A (3), manassantin B (4) and saucerneol B (5), have been isolated from the MeOH extract of Saurunis chinensis roots. The evaluation for protective effect of compounds 1-5 against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 2, and 5 showed significant protective effects with the EC50 values of 74.2±0.9, 111.3±0.8, 64.3±0.8 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC50 value of 86.2±0.5 μM.

KW - Hep G2 cells

KW - Hepatoprotective

KW - Saurunis chinensis

KW - Saururaceae

KW - Tacrine

UR - https://www.scopus.com/pages/publications/74349115629

M3 - Article

AN - SCOPUS:74349115629

SN - 0253-3073

VL - 38

SP - 176

EP - 180

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 2

ER -

Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells

Abstract

Keywords

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