High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes

Min Kyung Lee; Kyung Do Han; Jae Hyuk Lee; Seo Young Sohn; Jee Sun Jeong; Mee Kyoung Kim; Ki Hyun Baek; Ki Ho Song; Hyuk Sang Kwon

doi:10.1038/s41598-018-23905-2

High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes

Min Kyung Lee, Kyung Do Han, Jae Hyuk Lee, Seo Young Sohn, Jee Sun Jeong, Mee Kyoung Kim, Ki Hyun Baek, Ki Ho Song, Hyuk Sang Kwon

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Anemia is an independent risk factor for the development of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). Hemoglobin levels may also be associated with DR. We investigated the association between hemoglobin levels and DR risk. This cross-sectional, population-based study utilized data from 2,123 type 2 DM patients aged ≥30 years who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2012. Participants underwent an ophthalmic examination, including fundus photographs. A multiple logistic regression analysis was performed to evaluate the relationship between hemoglobin levels and DR risk. The mean hemoglobin levels in patients with and without DR were 13.76 ± 0.12 and 14.33 ± 0.05 g/dL, respectively, with anemia observed in 16.2 (2.4)% and 7.8 (0.8)%, respectively. A 19% decrease in DR risk was found with a 1.0-g/dL increase in hemoglobin level. DR risk exhibited a decreasing trend with increasing hemoglobin levels (P for trend <0.0001). The adjusted odds ratio of DR was significantly lower in the highest hemoglobin quartile. Our findings indicate that high hemoglobin levels are significantly related to a decreased DR risk in Korean type 2 diabetes.

Original language	English
Article number	5538
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-23905-2
State	Published - 1 Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41598-018-23905-2

Cite this

@article{e6290b0010e54c869cafd4b7af75e96f,

title = "High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes",

abstract = "Anemia is an independent risk factor for the development of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). Hemoglobin levels may also be associated with DR. We investigated the association between hemoglobin levels and DR risk. This cross-sectional, population-based study utilized data from 2,123 type 2 DM patients aged ≥30 years who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2012. Participants underwent an ophthalmic examination, including fundus photographs. A multiple logistic regression analysis was performed to evaluate the relationship between hemoglobin levels and DR risk. The mean hemoglobin levels in patients with and without DR were 13.76 ± 0.12 and 14.33 ± 0.05 g/dL, respectively, with anemia observed in 16.2 (2.4)% and 7.8 (0.8)%, respectively. A 19% decrease in DR risk was found with a 1.0-g/dL increase in hemoglobin level. DR risk exhibited a decreasing trend with increasing hemoglobin levels (P for trend <0.0001). The adjusted odds ratio of DR was significantly lower in the highest hemoglobin quartile. Our findings indicate that high hemoglobin levels are significantly related to a decreased DR risk in Korean type 2 diabetes.",

author = "Lee, {Min Kyung} and Han, {Kyung Do} and Lee, {Jae Hyuk} and Sohn, {Seo Young} and Jeong, {Jee Sun} and Kim, {Mee Kyoung} and Baek, {Ki Hyun} and Song, {Ki Ho} and Kwon, {Hyuk Sang}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-23905-2",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes

AU - Lee, Min Kyung

AU - Han, Kyung Do

AU - Lee, Jae Hyuk

AU - Sohn, Seo Young

AU - Jeong, Jee Sun

AU - Kim, Mee Kyoung

AU - Baek, Ki Hyun

AU - Song, Ki Ho

AU - Kwon, Hyuk Sang

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Anemia is an independent risk factor for the development of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). Hemoglobin levels may also be associated with DR. We investigated the association between hemoglobin levels and DR risk. This cross-sectional, population-based study utilized data from 2,123 type 2 DM patients aged ≥30 years who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2012. Participants underwent an ophthalmic examination, including fundus photographs. A multiple logistic regression analysis was performed to evaluate the relationship between hemoglobin levels and DR risk. The mean hemoglobin levels in patients with and without DR were 13.76 ± 0.12 and 14.33 ± 0.05 g/dL, respectively, with anemia observed in 16.2 (2.4)% and 7.8 (0.8)%, respectively. A 19% decrease in DR risk was found with a 1.0-g/dL increase in hemoglobin level. DR risk exhibited a decreasing trend with increasing hemoglobin levels (P for trend <0.0001). The adjusted odds ratio of DR was significantly lower in the highest hemoglobin quartile. Our findings indicate that high hemoglobin levels are significantly related to a decreased DR risk in Korean type 2 diabetes.

AB - Anemia is an independent risk factor for the development of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). Hemoglobin levels may also be associated with DR. We investigated the association between hemoglobin levels and DR risk. This cross-sectional, population-based study utilized data from 2,123 type 2 DM patients aged ≥30 years who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2012. Participants underwent an ophthalmic examination, including fundus photographs. A multiple logistic regression analysis was performed to evaluate the relationship between hemoglobin levels and DR risk. The mean hemoglobin levels in patients with and without DR were 13.76 ± 0.12 and 14.33 ± 0.05 g/dL, respectively, with anemia observed in 16.2 (2.4)% and 7.8 (0.8)%, respectively. A 19% decrease in DR risk was found with a 1.0-g/dL increase in hemoglobin level. DR risk exhibited a decreasing trend with increasing hemoglobin levels (P for trend <0.0001). The adjusted odds ratio of DR was significantly lower in the highest hemoglobin quartile. Our findings indicate that high hemoglobin levels are significantly related to a decreased DR risk in Korean type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=85044989721&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-23905-2

DO - 10.1038/s41598-018-23905-2

M3 - Article

C2 - 29615813

AN - SCOPUS:85044989721

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 5538

ER -

High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this