High-yield blood plasma separation by modulating inertial migration in a contraction-expansion array microchannel

M. G. Lee, S. Choi, H. J. Kim, H. K. Lim, J. H. Kim, N. Huh, J. K. Park

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

We report contraction-expansion array (CEA) microchannels for high-yield blood plasma separation utilizing differential inertial migration. An abrupt change of the cross-sectional area curves fluid streams and accelerates the flow velocity, which induces Dean flow. Utilizing the balance between inertial lift force and Dean drag force, we were able to separate blood plasma from human whole blood with a level of 62.2% yield. The CEA microfluidic device is easy to fabricate in a single layer fabrication process and expected to be useful for a simple blood plasma extraction on a chip with high-yield.

Original languageEnglish
Title of host publication2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages258-261
Number of pages4
DOIs
StatePublished - 2011
Event2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
Duration: 5 Jun 20119 Jun 2011

Publication series

Name2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Conference

Conference2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country/TerritoryChina
CityBeijing
Period5/06/119/06/11

Keywords

  • Contraction-expansion array (CEA)
  • Dean flow
  • Inertial microfluidics
  • Plasma separation

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