Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release

Sohyun Park; Dong Sup Kwag; Ung Yeol Lee; Dong Jin Lee; Kyung Taek Oh; Yu Seok Youn; Eun Seong Lee

doi:10.1002/pat.3198

Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release

Sohyun Park, Dong Sup Kwag, Ung Yeol Lee, Dong Jin Lee, Kyung Taek Oh, Yu Seok Youn, Eun Seong Lee

Department of Biomedical-Chemical Engineering

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In this study, porous poly(lactide-co-glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water-in-oil-in-water (W₁/O/W₂) multi-emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long-term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium.

Original language	English
Pages (from-to)	16-20
Number of pages	5
Journal	Polymers for Advanced Technologies
Volume	25
Issue number	1
DOIs	https://doi.org/10.1002/pat.3198
State	Published - Jan 2014

Keywords

Chronic obstructive pulmonary disease
Drug release kinetics
Poly(lactide-co-glycolide)
Porous microparticles
Tiotropium

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10.1002/pat.3198

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title = "Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release",

abstract = "In this study, porous poly(lactide-co-glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water-in-oil-in-water (W1/O/W2) multi-emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long-term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium.",

keywords = "Chronic obstructive pulmonary disease, Drug release kinetics, Poly(lactide-co-glycolide), Porous microparticles, Tiotropium",

author = "Sohyun Park and Kwag, \{Dong Sup\} and Lee, \{Ung Yeol\} and Lee, \{Dong Jin\} and Oh, \{Kyung Taek\} and Youn, \{Yu Seok\} and Lee, \{Eun Seong\}",

year = "2014",

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doi = "10.1002/pat.3198",

language = "English",

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T1 - Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release

AU - Park, Sohyun

AU - Kwag, Dong Sup

AU - Lee, Ung Yeol

AU - Lee, Dong Jin

AU - Oh, Kyung Taek

AU - Youn, Yu Seok

AU - Lee, Eun Seong

PY - 2014/1

Y1 - 2014/1

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AB - In this study, porous poly(lactide-co-glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water-in-oil-in-water (W1/O/W2) multi-emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long-term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium.

KW - Chronic obstructive pulmonary disease

KW - Drug release kinetics

KW - Poly(lactide-co-glycolide)

KW - Porous microparticles

KW - Tiotropium

UR - https://www.scopus.com/pages/publications/84890802310

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DO - 10.1002/pat.3198

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AN - SCOPUS:84890802310

SN - 1042-7147

VL - 25

SP - 16

EP - 20

JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

IS - 1

ER -

Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release

Abstract

Keywords

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