Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling

Naeun Lee; Min Sun Shin; Ki Soo Kang; Seung Ah Yoo; Subhasis Mohanty; Ruth R. Montgomery; Albert C. Shaw; Insoo Kang

doi:10.1016/j.clim.2014.03.003

Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling

Naeun Lee
, Min Sun Shin
, Ki Soo Kang
, Seung Ah Yoo
, Subhasis Mohanty
, Ruth R. Montgomery
, Albert C. Shaw
, Insoo Kang

Department of Biomedicine & Health Science

Yale University
Jeju National University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age. ≥. 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age. ≤. 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.

Original language	English
Pages (from-to)	101-110
Number of pages	10
Journal	Clinical Immunology
Volume	152
Issue number	1-2
DOIs	https://doi.org/10.1016/j.clim.2014.03.003
State	Published - May 2014

Bibliographical note

Funding Information:
We thank Ms. Laurie Kramer and Yale Center for Clinical Investigation (UL1 RR024139 from the NCRR) for assisting in the recruitment of human subjects. This work was supported in part by grants from the National Institutes of Health ( AG028069 , AG030834 to I.K.; U19 AI089992 and contract 272201100019C-3-0-1 to R.R.M. and A.C.S.; and K24 AG042489 to A.C.S.).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Human
IFN-γ
IL-15
Monocytes and aging

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10.1016/j.clim.2014.03.003

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title = "Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling",

abstract = "IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age. ≥. 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age. ≤. 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.",

keywords = "Human, IFN-γ, IL-15, Monocytes and aging",

author = "Naeun Lee and Shin, \{Min Sun\} and Kang, \{Ki Soo\} and Yoo, \{Seung Ah\} and Subhasis Mohanty and Montgomery, \{Ruth R.\} and Shaw, \{Albert C.\} and Insoo Kang",

note = "Funding Information: We thank Ms. Laurie Kramer and Yale Center for Clinical Investigation (UL1 RR024139 from the NCRR) for assisting in the recruitment of human subjects. This work was supported in part by grants from the National Institutes of Health ( AG028069 , AG030834 to I.K.; U19 AI089992 and contract 272201100019C-3-0-1 to R.R.M. and A.C.S.; and K24 AG042489 to A.C.S.).",

year = "2014",

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doi = "10.1016/j.clim.2014.03.003",

language = "English",

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journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

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AU - Lee, Naeun

AU - Shin, Min Sun

AU - Kang, Ki Soo

AU - Yoo, Seung Ah

AU - Mohanty, Subhasis

AU - Montgomery, Ruth R.

AU - Shaw, Albert C.

AU - Kang, Insoo

N1 - Funding Information: We thank Ms. Laurie Kramer and Yale Center for Clinical Investigation (UL1 RR024139 from the NCRR) for assisting in the recruitment of human subjects. This work was supported in part by grants from the National Institutes of Health ( AG028069 , AG030834 to I.K.; U19 AI089992 and contract 272201100019C-3-0-1 to R.R.M. and A.C.S.; and K24 AG042489 to A.C.S.).

PY - 2014/5

Y1 - 2014/5

N2 - IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age. ≥. 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age. ≤. 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.

AB - IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age. ≥. 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age. ≤. 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.

KW - Human

KW - IFN-γ

KW - IL-15

KW - Monocytes and aging

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DO - 10.1016/j.clim.2014.03.003

M3 - Article

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AN - SCOPUS:84897488461

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JF - Clinical Immunology

IS - 1-2

ER -

Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling

Abstract

Bibliographical note

UN SDGs

Keywords

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