Hyaluronate-Flt1 peptide conjugate/epirubicin micelles for theranostic application to liver cancers

Ki Su Kim; Sung Woo Hong; Hyemin Kim; Minsoo Cho; Seonghoon Kim; Wonhee Hur; Seok Hyun Yun; Seung Kew Yoon; Sei Kwang Hahn

doi:10.1039/c5ra07464a

Hyaluronate-Flt1 peptide conjugate/epirubicin micelles for theranostic application to liver cancers

Ki Su Kim
, Sung Woo Hong
, Hyemin Kim
, Minsoo Cho
, Seonghoon Kim
, Wonhee Hur
, Seok Hyun Yun
, Seung Kew Yoon
, Sei Kwang Hahn

Division of Gastroenterology

Massachusetts General Hospital
The Catholic University of Korea
Pohang University of Science and Technology
Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Cancer theranostic systems using polymeric micelles are emerging for simultaneous diagnosis and therapy. In this work, we have developed hyaluronate (HA)-Flt1 peptide conjugate micelles encapsulating epirubicin for theranostic treatment of hepatocellular carcinoma. Intravital bioimaging without labelling and in vivo anti-tumor therapeutic effect clearly confirmed the feasibility of HA-Flt1 peptide conjugate/epirubicin micelles for target-specific theranostic treatment of liver cancers.

Original language	English
Pages (from-to)	48615-48618
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	60
DOIs	https://doi.org/10.1039/c5ra07464a
State	Published - 2015

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c5ra07464a

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title = "Hyaluronate-Flt1 peptide conjugate/epirubicin micelles for theranostic application to liver cancers",

abstract = "Cancer theranostic systems using polymeric micelles are emerging for simultaneous diagnosis and therapy. In this work, we have developed hyaluronate (HA)-Flt1 peptide conjugate micelles encapsulating epirubicin for theranostic treatment of hepatocellular carcinoma. Intravital bioimaging without labelling and in vivo anti-tumor therapeutic effect clearly confirmed the feasibility of HA-Flt1 peptide conjugate/epirubicin micelles for target-specific theranostic treatment of liver cancers.",

author = "Kim, \{Ki Su\} and Hong, \{Sung Woo\} and Hyemin Kim and Minsoo Cho and Seonghoon Kim and Wonhee Hur and Yun, \{Seok Hyun\} and Yoon, \{Seung Kew\} and Hahn, \{Sei Kwang\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c5ra07464a",

language = "English",

volume = "5",

pages = "48615--48618",

journal = "RSC Advances",

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TY - JOUR

T1 - Hyaluronate-Flt1 peptide conjugate/epirubicin micelles for theranostic application to liver cancers

AU - Kim, Ki Su

AU - Hong, Sung Woo

AU - Kim, Hyemin

AU - Cho, Minsoo

AU - Kim, Seonghoon

AU - Hur, Wonhee

AU - Yun, Seok Hyun

AU - Yoon, Seung Kew

AU - Hahn, Sei Kwang

PY - 2015

Y1 - 2015

N2 - Cancer theranostic systems using polymeric micelles are emerging for simultaneous diagnosis and therapy. In this work, we have developed hyaluronate (HA)-Flt1 peptide conjugate micelles encapsulating epirubicin for theranostic treatment of hepatocellular carcinoma. Intravital bioimaging without labelling and in vivo anti-tumor therapeutic effect clearly confirmed the feasibility of HA-Flt1 peptide conjugate/epirubicin micelles for target-specific theranostic treatment of liver cancers.

AB - Cancer theranostic systems using polymeric micelles are emerging for simultaneous diagnosis and therapy. In this work, we have developed hyaluronate (HA)-Flt1 peptide conjugate micelles encapsulating epirubicin for theranostic treatment of hepatocellular carcinoma. Intravital bioimaging without labelling and in vivo anti-tumor therapeutic effect clearly confirmed the feasibility of HA-Flt1 peptide conjugate/epirubicin micelles for target-specific theranostic treatment of liver cancers.

UR - https://www.scopus.com/pages/publications/84930653450

U2 - 10.1039/c5ra07464a

DO - 10.1039/c5ra07464a

M3 - Article

AN - SCOPUS:84930653450

SN - 2046-2069

VL - 5

SP - 48615

EP - 48618

JO - RSC Advances

JF - RSC Advances

IS - 60

ER -

Hyaluronate-Flt1 peptide conjugate/epirubicin micelles for theranostic application to liver cancers

Abstract

Bibliographical note

UN SDGs

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